| 1 | Sun Sep 8 | vs Broncos | W26-20 | 1-0 | 1.000 | Lumen Field · Seattle, WA |
| 2 | Sun Sep 15 | atPatriots | W23-20 (OT) | 2-0 | 1.000 | Gillette Stadium · Foxborough, MA |
| 3 | Sun Sep 22 | vsDolphins | W24-3 | 3-0 | 1.000 | Lumen Field · Seattle, WA |
| 4 | Mon Sep 30 | atLions | L29-42 | 3-1 | .750 | Ford Field · Detroit, MI |
| 5 | Sun Oct 6 | vsGiants | L20-29 | 3-2 | .600 | Lumen Field · Seattle, WA |
| 6 | Thu Oct 10 | vs49ers | L24-36 | 3-3 | .500 | Lumen Field · Seattle, WA |
| 7 | Sun Oct 20 | atFalcons | W34-14 | 4-3 | .571 | Mercedes-Benz Stadium · Atlanta, GA |
| 8 | Sun Oct 27 | vsBills | L10-31 | 4-4 | .500 | Lumen Field · Seattle, WA |
| 9 | Sun Nov 3 | vsRams | L20-26 (OT) | 4-5 | .444 | Lumen Field · Seattle, WA |
| --bye week-- |
| 11 | Sun Nov 17 | at49ers | W20-17 | 5-5 | .500 | Levi's® Stadium · Santa Clara, CA |
| 12 | Sun Nov 24 | vsCardinals | W16-6 | 6-5 | .545 | Lumen Field · Seattle, WA |
| 13 | Sun Dec 1 | atJets | W26-21 | 7-5 | .583 | MetLife Stadium · East Rutherford, NJ |
| 14 | Sun Dec 8 | atCardinals | W30-18 | 8-5 | .615 | State Farm Stadium · Glendale, AZ |
| 15 | Sun Dec 15 | vsPackers | L13-30 | 8-6 | .571 | Lumen Field · Seattle, WA |
| 16 | Sun Dec 22 | vsVikings | L24-27 | 8-7 | .533 | Lumen Field · Seattle, WA |
| 17 | Thu Dec 26 | atBears | W6-3 | 9-7 | .563 | Soldier Field · Chicago, IL |
| 18 | Sun Jan 5 | atRams | W30-25 | 10-7 | .588 | SoFi Stadium · Inglewood, CA |
