| 1 | Mon Sep 12 | vs Broncos | W17-16 | 1-0 | 1.000 | Lumen Field · Seattle, WA |
| 2 | Sun Sep 18 | at49ers | L7-27 | 1-1 | .500 | Levi's® Stadium · Santa Clara, CA |
| 3 | Sun Sep 25 | vsFalcons | L23-27 | 1-2 | .333 | Lumen Field · Seattle, WA |
| 4 | Sun Oct 2 | atLions | W48-45 | 2-2 | .500 | Ford Field · Detroit, MI |
| 5 | Sun Oct 9 | atSaints | L32-39 | 2-3 | .400 | Caesars Superdome · New Orleans, LA |
| 6 | Sun Oct 16 | vsCardinals | W19-9 | 3-3 | .500 | Lumen Field · Seattle, WA |
| 7 | Sun Oct 23 | atChargers | W37-23 | 4-3 | .571 | SoFi Stadium · Inglewood, CA |
| 8 | Sun Oct 30 | vsGiants | W27-13 | 5-3 | .625 | Lumen Field · Seattle, WA |
| 9 | Sun Nov 6 | atCardinals | W31-21 | 6-3 | .667 | State Farm Stadium · Glendale, AZ |
| 10 | Sun Nov 13 | atBuccaneers | L16-21 | 6-4 | .600 | Allianz Arena · Munich, Germany |
| --bye week-- |
| 12 | Sun Nov 27 | vsRaiders | L34-40 (OT) | 6-5 | .545 | Lumen Field · Seattle, WA |
| 13 | Sun Dec 4 | atRams | W27-23 | 7-5 | .583 | SoFi Stadium · Inglewood, CA |
| 14 | Sun Dec 11 | vsPanthers | L24-30 | 7-6 | .538 | Lumen Field · Seattle, WA |
| 15 | Thu Dec 15 | vs49ers | L13-21 | 7-7 | .500 | Lumen Field · Seattle, WA |
| 16 | Sat Dec 24 | atChiefs | L10-24 | 7-8 | .467 | Arrowhead Stadium · Kansas City, MO |
| 17 | Sun Jan 1 | vsJets | W23-6 | 8-8 | .500 | Lumen Field · Seattle, WA |
| 18 | Sun Jan 8 | vsRams | W19-16 (OT) | 9-8 | .529 | Lumen Field · Seattle, WA |
| WC | Sat Jan 14 | at49ers | L23-41 | 9-8 | .529 | Levi's® Stadium · Santa Clara, CA |
