| 1 | Sun Sep 8 | vs Bengals | W21-20 | 1-0 | 1.000 | Lumen Field · Seattle, WA |
| 2 | Sun Sep 15 | at Steelers | W28-26 | 2-0 | 1.000 | Acrisure Stadium · Pittsburgh, PA |
| 3 | Sun Sep 22 | vs Saints | L27-33 | 2-1 | .667 | Lumen Field · Seattle, WA |
| 4 | Sun Sep 29 | at Cardinals | W27-10 | 3-1 | .750 | State Farm Stadium · Glendale, AZ |
| 5 | Thu Oct 3 | vs Rams | W30-29 | 4-1 | .800 | Lumen Field · Seattle, WA |
| 6 | Sun Oct 13 | at Browns | W32-28 | 5-1 | .833 | FirstEnergy Stadium · Cleveland, OH |
| 7 | Sun Oct 20 | vs Ravens | L16-30 | 5-2 | .714 | Lumen Field · Seattle, WA |
| 8 | Sun Oct 27 | at Falcons | W27-20 | 6-2 | .750 | Mercedes-Benz Stadium · Atlanta, GA |
| 9 | Sun Nov 3 | vs Buccaneers | W40-34 (OT) | 7-2 | .778 | Lumen Field · Seattle, WA |
| 10 | Mon Nov 11 | at 49ers | W27-24 (OT) | 8-2 | .800 | Levi's® Stadium · Santa Clara, CA |
| 11 | -- BYE WEEK -- |
| 12 | Sun Nov 24 | at Eagles | W17-9 | 9-2 | .818 | Lincoln Financial Field · Philadelphia, PA |
| 13 | Mon Dec 2 | vs Vikings | W37-30 | 10-2 | .833 | Lumen Field · Seattle, WA |
| 14 | Sun Dec 8 | atRams | L12-28 | 10-3 | .769 | SoFi Stadium · Inglewood, CA |
| 15 | Sun Dec 15 | at Panthers | W30-24 | 11-3 | .786 | Bank of America Stadium · Charlotte, NC |
| 16 | Sun Dec 22 | vsCardinals | L13-27 | 11-4 | .733 | Lumen Field · Seattle, WA |
| 17 | Sun Dec 29 | vs49ers | L21-26 | 11-5 | .688 | Lumen Field · Seattle, WA |
| WC | Sun Jan 5 | atEagles | W17-9 | 11-5 | .688 | Lincoln Financial Field · Philadelphia, PA |
| DIV | Sun Jan 12 | at Packers | L23-28 | 11-5 | .688 | Lambeau Field · Green Bay, WI |
