| 5 | Sun Oct 5 | vs Buccaneers | 4:05 PM | 3-1 | .750 | Lumen Field · Seattle, WA |
| 6 | Sun Oct 12 | atJaguars | 1:00 PM | 3-1 | .750 | TIAA Bank Field · Jacksonville, FL |
| 7 | Mon Oct 20 | vsTexans | 10:00 PM | 1-3 | .250 | Lumen Field · Seattle, WA |
| --bye week-- |
| 9 | Sun Nov 2 | atCommanders | 8:20 PM | 2-2 | .500 | FedEx Field · North Englewood, MD |
| 10 | Sun Nov 9 | vsCardinals | 4:05 PM | 2-2 | .500 | Lumen Field · Seattle, WA |
| 11 | Sun Nov 16 | atRams | 4:05 PM | 3-1 | .750 | SoFi Stadium · Inglewood, CA |
| 12 | Sun Nov 23 | atTitans | 1:00 PM | 0-4 | .000 | Nissan Stadium · Nashville, TN |
| 13 | Sun Nov 30 | vsVikings | 4:05 PM | 2-2 | .500 | Lumen Field · Seattle, WA |
| 14 | Sun Dec 7 | atFalcons | 1:00 PM | 2-2 | .500 | Mercedes-Benz Stadium · Atlanta, GA |
| 15 | Sun Dec 14 | vsColts | 4:25 PM | 3-1 | .750 | Lumen Field · Seattle, WA |
| 16 | Thu Dec 18 | vsRams | 8:15 PM | 3-1 | .750 | Lumen Field · Seattle, WA |
| 17 | TBD | atPanthers | TBD | 1-3 | .250 | Bank of America Stadium · Charlotte, NC |
| 18 | TBD | at49ers | TBD | 3-1 | .750 | Levi's® Stadium · Santa Clara, CA |
