| 1 | Sun Sep 10 | vs Rams | L13-30 | 0-1 | .000 | Lumen Field · Seattle, WA |
| 2 | Sun Sep 17 | atLions | W37-31 (OT) | 1-1 | .500 | Ford Field · Detroit, MI |
| 3 | Sun Sep 24 | vsPanthers | W37-27 | 2-1 | .667 | Lumen Field · Seattle, WA |
| 4 | Mon Oct 2 | atGiants | W24-3 | 3-1 | .750 | MetLife Stadium · East Rutherford, NJ |
| --bye week-- |
| 6 | Sun Oct 15 | atBengals | L13-17 | 3-2 | .600 | Paycor Stadium · Cincinnati, OH |
| 7 | Sun Oct 22 | vsCardinals | W20-10 | 4-2 | .667 | Lumen Field · Seattle, WA |
| 8 | Sun Oct 29 | vsBrowns | W24-20 | 5-2 | .714 | Lumen Field · Seattle, WA |
| 9 | Sun Nov 5 | atRavens | L3-37 | 5-3 | .625 | M&T Bank Stadium · Baltimore, MD |
| 10 | Sun Nov 12 | vsCommanders | W29-26 | 6-3 | .667 | Lumen Field · Seattle, WA |
| 11 | Sun Nov 19 | atRams | L16-17 | 6-4 | .600 | SoFi Stadium · Inglewood, CA |
| 12 | Thu Nov 23 | vs49ers | L13-31 | 6-5 | .545 | Lumen Field · Seattle, WA |
| 13 | Thu Nov 30 | atCowboys | L35-41 | 6-6 | .500 | AT&T Stadium · Arlington, TX |
| 14 | Sun Dec 10 | at49ers | L16-28 | 6-7 | .462 | Levi's® Stadium · Santa Clara, CA |
| 15 | Mon Dec 18 | vsEagles | W20-17 | 7-7 | .500 | Lumen Field · Seattle, WA |
| 16 | Sun Dec 24 | atTitans | W20-17 | 8-7 | .533 | Nissan Stadium · Nashville, TN |
| 17 | Sun Dec 31 | vsSteelers | L23-30 | 8-8 | .500 | Lumen Field · Seattle, WA |
| 18 | Sun Jan 7 | atCardinals | W21-20 | 9-8 | .529 | State Farm Stadium · Glendale, AZ |
