| 1 | Wed Oct 22 | at Hornets | L117-136 | 0-1 | .000 | | Spectrum Center · Charlotte, NC |
| 2 | Fri Oct 24 | vs Cavaliers | L124-131 | 0-2 | .000 | | Barclays Center · Brooklyn, NY |
| 3 | Sun Oct 26 | at Spurs | L107-118 | 0-3 | .000 | | AT&T Center · San Antonio, TX |
| 4 | Mon Oct 27 | at Rockets | L109-137 | 0-4 | .000 | | Toyota Center · Houston, TX |
| 5 | Wed Oct 29 | vs Hawks | L112-117 | 0-5 | .000 | | Barclays Center · Brooklyn, NY |
| 6 | Sun Nov 2 | vs 76ers | L105-129 | 0-6 | .000 | | Barclays Center · Brooklyn, NY |
| 7 | Mon Nov 3 | vs T-wolves | L109-125 | 0-7 | .000 | Peacock | Barclays Center · Brooklyn, NY |
| 8 | Wed Nov 5 | at Pacers | W112-103 | 1-7 | .125 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 9 | Fri Nov 7 | vs Pistons | L107-125 | 1-8 | .111 | | Barclays Center · Brooklyn, NY |
| 10 | Sun Nov 9 | at Knicks | L98-134 | 1-9 | .100 | | Madison Square Garden · Manhattan, NY |
| 11 | Tue Nov 11 | vs Raptors | L109-119 | 1-10 | .091 | | Barclays Center · Brooklyn, NY |
| 12 | Fri Nov 14 | at Magic | L98-105 | 1-11 | .083 | | Kia Center · Orlando, FL |
| 13 | Sun Nov 16 | at Wizards | W129-106 | 2-11 | .154 | | Capital One Arena · Washington, D.C. |
| 14 | Tue Nov 18 | vs Celtics | L99-113 | 2-12 | .143 | | Barclays Center · Brooklyn, NY |
| 15 | Fri Nov 21 | at Celtics | W113-105 | 3-12 | .200 | | TD Garden · Boston, MA |
| 16 | Sun Nov 23 | at Raptors | L109-119 | 3-13 | .188 | | Scotiabank Arena · Toronto, ON |
| 17 | Mon Nov 24 | vs Knicks | L100-113 | 3-14 | .176 | | Barclays Center · Brooklyn, NY |
| 18 | Fri Nov 28 | vs 76ers | L103-115 | 3-15 | .167 | | Barclays Center · Brooklyn, NY |
| 19 | Sat Nov 29 | at Bucks | L99-116 | 3-16 | .158 | | Fiserv Forum · Milwaukee, WI |
| 20 | Mon Dec 1 | vs Hornets | W116-103 | 4-16 | .200 | | Barclays Center · Brooklyn, NY |
| 21 | Wed Dec 3 | at Bulls | W113-103 | 5-16 | .238 | | United Center · Chicago, IL |
| 22 | Thu Dec 4 | vs Jazz | L110-123 | 5-17 | .227 | | Barclays Center · Brooklyn, NY |
| 23 | Sat Dec 6 | vs Pelicans | W119-101 | 6-17 | .261 | | Barclays Center · Brooklyn, NY |
| 24 | Fri Dec 12 | at Mavericks | L111-119 | 6-18 | .250 | | American Airlines Center · Dallas, TX |
| 25 | Sun Dec 14 | vs Bucks | W127-82 | 7-18 | .280 | | Barclays Center · Brooklyn, NY |
| 26 | Thu Dec 18 | vs Heat | L95-106 | 7-19 | .269 | | Barclays Center · Brooklyn, NY |
| 27 | Sun Dec 21 | vs Raptors | W96-81 | 8-19 | .296 | | Barclays Center · Brooklyn, NY |
| 28 | Tue Dec 23 | at 76ers | W114-106 | 9-19 | .321 | | Wells Fargo Center · Philadelphia, PA |
| 29 | Sat Dec 27 | at T-wolves | W123-107 | 10-19 | .345 | | Target Center · Minneapolis, MN |
| 30 | Mon Dec 29 | vs Warriors | L107-120 | 10-20 | .333 | | Barclays Center · Brooklyn, NY |
| 31 | Thu Jan 1 | vs Rockets | L96-120 | 10-21 | .323 | | Barclays Center · Brooklyn, NY |
| 32 | Fri Jan 2 | at Wizards | L99-119 | 10-22 | .313 | | Capital One Arena · Washington, D.C. |
| 33 | Sun Jan 4 | vs Nuggets | W127-115 | 11-22 | .333 | | Barclays Center · Brooklyn, NY |
| 34 | Wed Jan 7 | vs Magic | L103-104 (OT) | 11-23 | .324 | | Barclays Center · Brooklyn, NY |
| 35 | Fri Jan 9 | vs Clippers | L105-121 | 11-24 | .314 | | Barclays Center · Brooklyn, NY |
| 36 | Sun Jan 11 | at Grizzlies | L98-103 | 11-25 | .306 | | FedExForum · Memphis, TN |
| 37 | Mon Jan 12 | at Mavericks | L105-113 | 11-26 | .297 | | American Airlines Center · Dallas, TX |
| 38 | Wed Jan 14 | at Pelicans | L113-116 | 11-27 | .289 | | Smoothie King Center · New Orleans, LA |
| 39 | Fri Jan 16 | vs Bulls | W112-109 | 12-27 | .308 | | Barclays Center · Brooklyn, NY |
| 40 | Sun Jan 18 | at Bulls | L102-124 | 12-28 | .300 | | United Center · Chicago, IL |
| 41 | Mon Jan 19 | vs Suns | L117-126 | 12-29 | .293 | | Barclays Center · Brooklyn, NY |
| 42 | Wed Jan 21 | at Knicks | L66-120 | 12-30 | .286 | | Madison Square Garden · Manhattan, NY |
| 43 | Fri Jan 23 | vs Celtics | L126-130 (2OT) | 12-31 | .279 | | Barclays Center · Brooklyn, NY |
| 44 | Sun Jan 25 | at Clippers | L89-126 | 12-32 | .273 | | Intuit Dome · Inglewood, CA |
| 45 | Tue Jan 27 | at Suns | L102-106 | 12-33 | .267 | | Mortgage Matchup Center · Phoenix, AZ |
| 46 | Thu Jan 29 | at Nuggets | L103-107 | 12-34 | .261 | | Ball Arena · Denver, CO |
| 47 | Fri Jan 30 | at Jazz | W109-99 | 13-34 | .277 | | Vivint Arena · Salt Lake City, UT |
| 48 | Sun Feb 1 | at Pistons | L77-130 | 13-35 | .271 | | Little Caesars Arena · Detroit, MI |
| 49 | Tue Feb 3 | vs Lakers | L109-125 | 13-36 | .265 | | Barclays Center · Brooklyn, NY |
| 50 | Thu Feb 5 | at Magic | L98-118 | 13-37 | .260 | | Kia Center · Orlando, FL |
| 51 | Sat Feb 7 | vs Wizards | W127-113 | 14-37 | .275 | | Barclays Center · Brooklyn, NY |
| 52 | Mon Feb 9 | vs Bulls | W123-115 | 15-37 | .288 | | Barclays Center · Brooklyn, NY |
| 53 | Wed Feb 11 | vs Pacers | L110-115 | 15-38 | .283 | | Barclays Center · Brooklyn, NY |
| --all-star break-- |
| 54 | Thu Feb 19 | at Cavaliers | L84-112 | 15-39 | .278 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 55 | Fri Feb 20 | at Thunder | L86-105 | 15-40 | .273 | | Paycom Center · Oklahoma City, OK |
| 56 | Sun Feb 22 | at Hawks | L104-115 | 15-41 | .268 | | State Farm Arena · Atlanta, GA |
| 57 | Tue Feb 24 | vs Mavericks | L114-123 | 15-42 | .263 | | Barclays Center · Brooklyn, NY |
| 58 | Thu Feb 26 | vs Spurs | L110-126 | 15-43 | .259 | | Barclays Center · Brooklyn, NY |
| 59 | Fri Feb 27 | at Celtics | L111-148 | 15-44 | .254 | | TD Garden · Boston, MA |
| 60 | Sun Mar 1 | vs Cavaliers | L102-106 | 15-45 | .250 | | Barclays Center · Brooklyn, NY |
| 61 | Tue Mar 3 | at Heat | L98-124 | 15-46 | .246 | | Kaseya Center · Miami, FL |