| 1 | Wed Oct 23 | vs Grizzlies | W120-101 | 1-0 | 1.000 | | Kaseya Center · Miami, FL |
| 2 | Sat Oct 26 | at Bucks | W131-126 (OT) | 2-0 | 1.000 | NBA TV | Fiserv Forum · Milwaukee, WI |
| 3 | Sun Oct 27 | at T-wolves | L109-116 | 2-1 | .667 | | Target Center · Minneapolis, MN |
| 4 | Tue Oct 29 | vs Hawks | W112-97 | 3-1 | .750 | NBA TV | Kaseya Center · Miami, FL |
| 5 | Thu Oct 31 | at Hawks | W106-97 | 4-1 | .800 | TNT | State Farm Arena · Atlanta, GA |
| 6 | Sun Nov 3 | vs Rockets | W129-100 | 5-1 | .833 | | Kaseya Center · Miami, FL |
| 7 | Tue Nov 5 | at Nuggets | L89-109 | 5-2 | .714 | | Ball Arena · Denver, CO |
| 8 | Thu Nov 7 | at Suns | W124-108 | 6-2 | .750 | | Footprint Center · Phoenix, AZ |
| 9 | Fri Nov 8 | at Lakers | L80-95 | 6-3 | .667 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 10 | Tue Nov 12 | vs Pistons | W117-108 | 7-3 | .700 | | Kaseya Center · Miami, FL |
| 11 | Thu Nov 14 | at Cavaliers | W108-97 | 8-3 | .727 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 12 | Sat Nov 16 | vs Pelicans | W109-94 | 9-3 | .750 | | Kaseya Center · Miami, FL |
| 13 | Wed Nov 20 | vs Cavaliers | W124-100 | 10-3 | .769 | | Kaseya Center · Miami, FL |
| 14 | Fri Nov 22 | at Bulls | W116-108 | 11-3 | .786 | | United Center · Chicago, IL |
| 15 | Sat Nov 23 | at 76ers | L86-113 | 11-4 | .733 | NBA TV | Wells Fargo Center · Philadelphia, PA |
| 16 | Mon Nov 25 | vs Hornets | W117-100 | 12-4 | .750 | | Kaseya Center · Miami, FL |
| 17 | Wed Nov 27 | at Rockets | L108-117 | 12-5 | .706 | | Toyota Center · Houston, TX |
| 18 | Fri Nov 29 | vs Warriors | W122-105 | 13-5 | .722 | | Kaseya Center · Miami, FL |
| 19 | Sun Dec 1 | at Nets | W109-106 | 14-5 | .737 | | Barclays Center · Brooklyn, NY |
| 20 | Tue Dec 3 | at Raptors | W121-110 (OT) | 15-5 | .750 | | Scotiabank Arena · Toronto, ON |
| 21 | Wed Dec 4 | at Celtics | L93-112 | 15-6 | .714 | | TD Garden · Boston, MA |
| 22 | Fri Dec 6 | vs Wizards | W112-103 | 16-6 | .727 | | Kaseya Center · Miami, FL |
| 23 | Sun Dec 8 | vs Bulls | W110-105 (OT) | 17-6 | .739 | | Kaseya Center · Miami, FL |
| 24 | Tue Dec 10 | vs Hawks | W135-121 (OT) | 18-6 | .750 | | Kaseya Center · Miami, FL |
| 25 | Fri Dec 13 | vs Lakers | L110-113 | 18-7 | .720 | ESPN | Kaseya Center · Miami, FL |
| 26 | Sat Dec 14 | at Mavericks | W122-118 (OT) | 19-7 | .731 | | American Airlines Center · Dallas, TX |
| 27 | Mon Dec 16 | at Grizzlies | L111-118 | 19-8 | .704 | | FedExForum · Memphis, TN |
| 28 | Wed Dec 18 | at 76ers | W108-104 | 20-8 | .714 | ESPN | Wells Fargo Center · Philadelphia, PA |
| 29 | Fri Dec 20 | vs Knicks | W129-114 | 21-8 | .724 | | Kaseya Center · Miami, FL |
| 30 | Mon Dec 23 | vs Jazz | W107-104 | 22-8 | .733 | | Kaseya Center · Miami, FL |
| 31 | Fri Dec 27 | vs Pacers | W113-112 | 23-8 | .742 | | Kaseya Center · Miami, FL |
| 32 | Sat Dec 28 | vs 76ers | W117-116 (OT) | 24-8 | .750 | | Kaseya Center · Miami, FL |
| 33 | Mon Dec 30 | at Wizards | L105-123 | 24-9 | .727 | | Capital One Arena · Washington, D.C. |
| 34 | Thu Jan 2 | vs Raptors | W84-76 | 25-9 | .735 | NBA TV | Kaseya Center · Miami, FL |
| 35 | Fri Jan 3 | at Magic | L85-105 | 25-10 | .714 | | Amway Center · Orlando, FL |
| 36 | Sun Jan 5 | vs Blazers | W122-111 | 26-10 | .722 | | Kaseya Center · Miami, FL |
| 37 | Wed Jan 8 | at Pacers | W122-108 | 27-10 | .730 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 38 | Fri Jan 10 | at Nets | L113-117 | 27-11 | .711 | | Barclays Center · Brooklyn, NY |
| 39 | Sun Jan 12 | at Knicks | L121-124 | 27-12 | .692 | | Madison Square Garden · Manhattan, NY |
| 40 | Wed Jan 15 | vs Spurs | W106-100 | 28-12 | .700 | | Kaseya Center · Miami, FL |
| 41 | Fri Jan 17 | at Thunder | W115-108 | 29-12 | .707 | | Paycom Center · Oklahoma City, OK |
| 42 | Sun Jan 19 | at Spurs | L102-107 | 29-13 | .690 | | AT&T Center · San Antonio, TX |
| 43 | Mon Jan 20 | vs Kings | W118-113 (OT) | 30-13 | .698 | | Kaseya Center · Miami, FL |
| 44 | Wed Jan 22 | vs Wizards | W134-129 (OT) | 31-13 | .705 | | Kaseya Center · Miami, FL |
| 45 | Fri Jan 24 | vs Clippers | L117-122 | 31-14 | .689 | ESPN | Kaseya Center · Miami, FL |
| 46 | Mon Jan 27 | vs Magic | W113-92 | 32-14 | .696 | | Kaseya Center · Miami, FL |
| 47 | Tue Jan 28 | vs Celtics | L101-109 | 32-15 | .681 | TNT | Kaseya Center · Miami, FL |
| 48 | Sat Feb 1 | at Magic | W102-89 | 33-15 | .688 | | Amway Center · Orlando, FL |
| 49 | Mon Feb 3 | vs 76ers | W137-106 | 34-15 | .694 | NBA TV | Kaseya Center · Miami, FL |
| 50 | Wed Feb 5 | at Clippers | L111-128 | 34-16 | .680 | ESPN | Intuit Dome · Inglewood, CA |
| 51 | Fri Feb 7 | at Kings | L97-105 | 34-17 | .667 | | Golden 1 Center · Sacramento, CA |
| 52 | Sun Feb 9 | at Blazers | L109-115 | 34-18 | .654 | | Moda Center · Portland, OR |
| 53 | Mon Feb 10 | at Warriors | W113-101 | 35-18 | .660 | | Chase Center · San Francisco, CA |
| 54 | Wed Feb 12 | at Jazz | L101-116 | 35-19 | .648 | | Vivint Arena · Salt Lake City, UT |
| 55 | Thu Feb 20 | at Hawks | L124-129 | 35-20 | .636 | | State Farm Arena · Atlanta, GA |
| 56 | Sat Feb 22 | vs Cavaliers | W124-105 | 36-20 | .643 | | Kaseya Center · Miami, FL |
| 57 | Mon Feb 24 | at Cavaliers | L119-125 (OT) | 36-21 | .632 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 58 | Wed Feb 26 | vs T-wolves | L126-129 | 36-22 | .621 | | Kaseya Center · Miami, FL |
| 59 | Fri Feb 28 | vs Mavericks | W126-118 | 37-22 | .627 | | Kaseya Center · Miami, FL |
| 60 | Sat Feb 29 | vs Nets | W116-113 | 38-22 | .633 | | Kaseya Center · Miami, FL |
| 61 | Mon Mar 2 | vs Bucks | W105-89 | 39-22 | .639 | NBA TV | Kaseya Center · Miami, FL |
| 62 | Wed Mar 4 | vs Magic | W116-113 | 40-22 | .645 | | Kaseya Center · Miami, FL |
| 63 | Fri Mar 6 | at Pelicans | L104-110 | 40-23 | .635 | ESPN | Smoothie King Center · New Orleans, LA |
| 64 | Sun Mar 8 | at Wizards | W100-89 | 41-23 | .641 | | Capital One Arena · Washington, D.C. |
| 65 | Wed Mar 11 | vs Hornets | L98-109 | 41-24 | .631 | | Kaseya Center · Miami, FL |
| 66 | Sat Aug 1 | at Nuggets | W125-105 | 42-24 | .636 | ESPN | Ball Arena · Denver, CO |
| 67 | Mon Aug 3 | vs Raptors | L103-107 | 42-25 | .627 | NBA TV | Kaseya Center · Miami, FL |
| 68 | Tue Aug 4 | vs Celtics | W112-106 | 43-25 | .632 | TNT | Kaseya Center · Miami, FL |
| 69 | Thu Aug 6 | at Bucks | L116-130 | 43-26 | .623 | TNT | Fiserv Forum · Milwaukee, WI |
| 70 | Sat Aug 8 | vs Suns | L112-119 | 43-27 | .614 | | Kaseya Center · Miami, FL |
| 71 | Mon Aug 10 | vs Pacers | W114-92 | 44-27 | .620 | | Kaseya Center · Miami, FL |
| 72 | Wed Aug 12 | at Thunder | L115-116 | 44-28 | .611 | | Paycom Center · Oklahoma City, OK |
| 73 | Fri Aug 14 | at Pacers | L92-109 | 44-29 | .603 | ESPN | Gainbridge Fieldhouse · Indianapolis, IN |
| 1 | Tue Aug 18 | at Pacers | W113-101 | 1-0 | 1.000 | TNT | Gainbridge Fieldhouse · Indianapolis, IN |
| 2 | Thu Aug 20 | at Pacers | W109-100 | 2-0 | 1.000 | ESPN | Gainbridge Fieldhouse · Indianapolis, IN |
| 3 | Sat Aug 22 | vs Pacers | W124-115 | 3-0 | 1.000 | TNT | Kaseya Center · Miami, FL |
| 4 | Mon Aug 24 | vs Pacers | W99-87 | 4-0 | 1.000 | TNT | Kaseya Center · Miami, FL |
| 1 | Mon Aug 31 | at Bucks | W115-104 | 1-0 | 1.000 | TNT | Fiserv Forum · Milwaukee, WI |
| 2 | Wed Sep 2 | at Bucks | W116-114 | 2-0 | 1.000 | ESPN | Fiserv Forum · Milwaukee, WI |
| 3 | Fri Sep 4 | vs Bucks | W115-100 | 3-0 | 1.000 | TNT | Kaseya Center · Miami, FL |
| 4 | Sun Sep 6 | vs Bucks | L115-118 (OT) | 3-1 | .750 | ABC | Kaseya Center · Miami, FL |
| 5 | Tue Sep 8 | at Bucks | W103-94 | 4-1 | .800 | TNT | Fiserv Forum · Milwaukee, WI |
| 1 | Tue Sep 15 | at Celtics | W117-114 (OT) | 1-0 | 1.000 | ESPN | TD Garden · Boston, MA |
| 2 | Thu Sep 17 | at Celtics | W106-101 | 2-0 | 1.000 | ESPN | TD Garden · Boston, MA |
| 3 | Sat Sep 19 | vs Celtics | L106-117 | 2-1 | .667 | ESPN | Kaseya Center · Miami, FL |
| 4 | Wed Sep 23 | vs Celtics | W112-109 | 3-1 | .750 | ESPN | Kaseya Center · Miami, FL |
| 5 | Fri Sep 25 | at Celtics | L108-121 | 3-2 | .600 | ESPN | TD Garden · Boston, MA |
| 6 | Sun Sep 27 | vs Celtics | W125-113 | 4-2 | .667 | ESPN | Kaseya Center · Miami, FL |
| 1 | Wed Sep 30 | at Lakers | L98-116 | 0-1 | .000 | ABC | Crypto.com Arena · Los Angeles, CA |
| 2 | Fri Oct 2 | at Lakers | L114-124 | 0-2 | .000 | ABC | Crypto.com Arena · Los Angeles, CA |
| 3 | Sun Oct 4 | vs Lakers | W115-104 | 1-2 | .333 | ABC | Kaseya Center · Miami, FL |
| 4 | Tue Oct 6 | vs Lakers | L96-102 | 1-3 | .250 | ABC | Kaseya Center · Miami, FL |
| 5 | Fri Oct 9 | at Lakers | W111-108 | 2-3 | .400 | ABC | Crypto.com Arena · Los Angeles, CA |
| 6 | Sun Oct 11 | vs Lakers | L93-106 | 2-4 | .333 | ABC | Kaseya Center · Miami, FL |