| 1 | Sun Sep 13 | vs Cardinals | 4:25 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 2 | Sun Sep 20 | vsRaiders | 4:05 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 3 | Sun Sep 27 | atBills | 1:00 PM | 0-0 | .000 | Highmark Stadium · Orchard Park, NY |
| 4 | Sun Oct 4 | atSeahawks | 4:25 PM | 0-0 | .000 | Lumen Field · Seattle, WA |
| 5 | Sun Oct 11 | vsBroncos | 4:05 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 6 | Sun Oct 18 | atChiefs | 4:25 PM | 0-0 | .000 | Arrowhead Stadium · Kansas City, MO |
| --bye week-- |
| 8 | Sun Nov 1 | atRams | 4:05 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 9 | Sun Nov 8 | vsTexans | 4:05 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 10 | Mon Nov 16 | atRavens | 8:15 PM | 0-0 | .000 | M&T Bank Stadium · Baltimore, MD |
| 11 | Sun Nov 22 | vsJets | 4:05 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 12 | Sun Nov 29 | vsPatriots | 8:20 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 13 | Sun Dec 6 | atBuccaneers | 1:00 PM | 0-0 | .000 | Raymond James Stadium · Tampa, FL |
| 14 | Sun Dec 13 | atRaiders | 4:05 PM | 0-0 | .000 | Allegiant Stadium · Las Vegas, NV |
| 15 | Thu Dec 17 | vs49ers | 8:15 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 16 | Sun Dec 27 | atDolphins | 1:00 PM | 0-0 | .000 | Hard Rock Stadium · Miami Gardens, FL |
| 17 | TBD | vsChiefs | TBD | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 18 | TBD | atBroncos | TBD | 0-0 | .000 | Empower Field at Mile High · Denver, CO |
