| 1 | Sun Sep 8 | vs Steelers | W33-3 | 1-0 | 1.000 | Gillette Stadium · Foxborough, MA |
| 2 | Sun Sep 15 | atDolphins | W43-0 | 2-0 | 1.000 | Hard Rock Stadium · Miami Gardens, FL |
| 3 | Sun Sep 22 | vsJets | W30-14 | 3-0 | 1.000 | Gillette Stadium · Foxborough, MA |
| 4 | Sun Sep 29 | atBills | W16-10 | 4-0 | 1.000 | Highmark Stadium · Orchard Park, NY |
| 5 | Sun Oct 6 | atCommanders | W33-7 | 5-0 | 1.000 | FedEx Field · North Englewood, MD |
| 6 | Thu Oct 10 | vsGiants | W35-14 | 6-0 | 1.000 | Gillette Stadium · Foxborough, MA |
| 7 | Mon Oct 21 | atJets | W33-0 | 7-0 | 1.000 | MetLife Stadium · East Rutherford, NJ |
| 8 | Sun Oct 27 | vsBrowns | W27-13 | 8-0 | 1.000 | Gillette Stadium · Foxborough, MA |
| 9 | Sun Nov 3 | atRavens | L20-37 | 8-1 | .889 | M&T Bank Stadium · Baltimore, MD |
| --bye week-- |
| 11 | Sun Nov 17 | atEagles | W17-10 | 9-1 | .900 | Lincoln Financial Field · Philadelphia, PA |
| 12 | Sun Nov 24 | vsCowboys | W13-9 | 10-1 | .909 | Gillette Stadium · Foxborough, MA |
| 13 | Sun Dec 1 | atTexans | L22-28 | 10-2 | .833 | NRG Stadium · Houston, TX |
| 14 | Sun Dec 8 | vsChiefs | L16-23 | 10-3 | .769 | Gillette Stadium · Foxborough, MA |
| 15 | Sun Dec 15 | atBengals | W34-13 | 11-3 | .786 | Paycor Stadium · Cincinnati, OH |
| 16 | Sat Dec 21 | vsBills | W24-17 | 12-3 | .800 | Gillette Stadium · Foxborough, MA |
| 17 | Sun Dec 29 | vsDolphins | L24-27 | 12-4 | .750 | Gillette Stadium · Foxborough, MA |
| WC | Sat Jan 4 | vsTitans | L13-20 | 12-4 | .750 | Gillette Stadium · Foxborough, MA |
