| 1 | Sun Sep 11 | at Dolphins | L7-20 | 0-1 | .000 | Hard Rock Stadium · Miami Gardens, FL |
| 2 | Sun Sep 18 | atSteelers | W17-14 | 1-1 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 3 | Sun Sep 25 | vsRavens | L26-37 | 1-2 | .333 | Gillette Stadium · Foxborough, MA |
| 4 | Sun Oct 2 | atPackers | L24-27 (OT) | 1-3 | .250 | Lambeau Field · Green Bay, WI |
| 5 | Sun Oct 9 | vsLions | W29-0 | 2-3 | .400 | Gillette Stadium · Foxborough, MA |
| 6 | Sun Oct 16 | atBrowns | W38-15 | 3-3 | .500 | FirstEnergy Stadium · Cleveland, OH |
| 7 | Mon Oct 24 | vsBears | L14-33 | 3-4 | .429 | Gillette Stadium · Foxborough, MA |
| 8 | Sun Oct 30 | atJets | W22-17 | 4-4 | .500 | MetLife Stadium · East Rutherford, NJ |
| 9 | Sun Nov 6 | vsColts | W26-3 | 5-4 | .556 | Gillette Stadium · Foxborough, MA |
| --bye week-- |
| 11 | Sun Nov 20 | vsJets | W10-3 | 6-4 | .600 | Gillette Stadium · Foxborough, MA |
| 12 | Thu Nov 24 | atVikings | L26-33 | 6-5 | .545 | U.S. Bank Stadium · Minneapolis, MN |
| 13 | Thu Dec 1 | vsBills | L10-24 | 6-6 | .500 | Gillette Stadium · Foxborough, MA |
| 14 | Mon Dec 12 | atCardinals | W27-13 | 7-6 | .538 | State Farm Stadium · Glendale, AZ |
| 15 | Sun Dec 18 | atRaiders | L24-30 | 7-7 | .500 | Allegiant Stadium · Las Vegas, NV |
| 16 | Sat Dec 24 | vsBengals | L18-22 | 7-8 | .467 | Gillette Stadium · Foxborough, MA |
| 17 | Sun Jan 1 | vsDolphins | W23-21 | 8-8 | .500 | Gillette Stadium · Foxborough, MA |
| 18 | Sun Jan 8 | atBills | L23-35 | 8-9 | .471 | Highmark Stadium · Orchard Park, NY |
