| 1 | Sun Sep 8 | at Bengals | W16-10 | 1-0 | 1.000 | Paycor Stadium · Cincinnati, OH |
| 2 | Sun Sep 15 | vsSeahawks | L20-23 (OT) | 1-1 | .500 | Gillette Stadium · Foxborough, MA |
| 3 | Thu Sep 19 | atJets | L3-24 | 1-2 | .333 | MetLife Stadium · East Rutherford, NJ |
| 4 | Sun Sep 29 | at49ers | L13-30 | 1-3 | .250 | Levi's® Stadium · Santa Clara, CA |
| 5 | Sun Oct 6 | vsDolphins | L10-15 | 1-4 | .200 | Gillette Stadium · Foxborough, MA |
| 6 | Sun Oct 13 | vsTexans | L21-41 | 1-5 | .167 | Gillette Stadium · Foxborough, MA |
| 7 | Sun Oct 20 | atJaguars | L16-32 | 1-6 | .143 | Wembley Stadium · London, England |
| 8 | Sun Oct 27 | vsJets | W25-22 | 2-6 | .250 | Gillette Stadium · Foxborough, MA |
| 9 | Sun Nov 3 | atTitans | L17-20 (OT) | 2-7 | .222 | Nissan Stadium · Nashville, TN |
| 10 | Sun Nov 10 | atBears | W19-3 | 3-7 | .300 | Soldier Field · Chicago, IL |
| 11 | Sun Nov 17 | vsRams | L22-28 | 3-8 | .273 | Gillette Stadium · Foxborough, MA |
| 12 | Sun Nov 24 | atDolphins | L15-34 | 3-9 | .250 | Hard Rock Stadium · Miami Gardens, FL |
| 13 | Sun Dec 1 | vsColts | L24-25 | 3-10 | .231 | Gillette Stadium · Foxborough, MA |
| --bye week-- |
| 15 | Sun Dec 15 | atCardinals | L17-30 | 3-11 | .214 | State Farm Stadium · Glendale, AZ |
| 16 | Sun Dec 22 | atBills | L21-24 | 3-12 | .200 | Highmark Stadium · Orchard Park, NY |
| 17 | Sat Dec 28 | vsChargers | L7-40 | 3-13 | .188 | Gillette Stadium · Foxborough, MA |
| 18 | Sun Jan 5 | vsBills | W23-16 | 4-13 | .235 | Gillette Stadium · Foxborough, MA |
