| 4 | Sun Sep 28 | vs Panthers | 1:00 PM | 1-2 | .333 | Gillette Stadium · Foxborough, MA |
| 5 | Sun Oct 5 | atBills | 8:20 PM | 3-0 | 1.000 | Highmark Stadium · Orchard Park, NY |
| 6 | Sun Oct 12 | atSaints | 4:25 PM | 0-3 | .000 | Caesars Superdome · New Orleans, LA |
| 7 | Sun Oct 19 | atTitans | 1:00 PM | 0-3 | .000 | Nissan Stadium · Nashville, TN |
| 8 | Sun Oct 26 | vsBrowns | 1:00 PM | 1-2 | .333 | Gillette Stadium · Foxborough, MA |
| 9 | Sun Nov 2 | vsFalcons | 1:00 PM | 1-2 | .333 | Gillette Stadium · Foxborough, MA |
| 10 | Sun Nov 9 | atBuccaneers | 1:00 PM | 3-0 | 1.000 | Raymond James Stadium · Tampa, FL |
| 11 | Thu Nov 13 | vsJets | 8:15 PM | 0-3 | .000 | Gillette Stadium · Foxborough, MA |
| 12 | Sun Nov 23 | atBengals | 1:00 PM | 2-1 | .667 | Paycor Stadium · Cincinnati, OH |
| 13 | Mon Dec 1 | vsGiants | 8:15 PM | 0-3 | .000 | Gillette Stadium · Foxborough, MA |
| --bye week-- |
| 15 | Sun Dec 14 | vsBills | 1:00 PM | 3-0 | 1.000 | Gillette Stadium · Foxborough, MA |
| 16 | Sun Dec 21 | atRavens | 1:00 PM | 1-2 | .333 | M&T Bank Stadium · Baltimore, MD |
| 17 | Sun Dec 28 | atJets | 1:00 PM | 0-3 | .000 | MetLife Stadium · East Rutherford, NJ |
| 18 | TBD | vsDolphins | TBD | 0-3 | .000 | Gillette Stadium · Foxborough, MA |
