| 1 | Sun Sep 13 | vs Dolphins | W21-11 | 1-0 | 1.000 | Gillette Stadium · Foxborough, MA |
| 2 | Sun Sep 20 | atSeahawks | L30-35 | 1-1 | .500 | Lumen Field · Seattle, WA |
| 3 | Sun Sep 27 | vsRaiders | W36-20 | 2-1 | .667 | Gillette Stadium · Foxborough, MA |
| 4 | Mon Oct 5 | atChiefs | L10-26 | 2-2 | .500 | Arrowhead Stadium · Kansas City, MO |
| --bye week-- |
| 6 | Sun Oct 18 | vsBroncos | L12-18 | 2-3 | .400 | Gillette Stadium · Foxborough, MA |
| 7 | Sun Oct 25 | vs49ers | L6-33 | 2-4 | .333 | Gillette Stadium · Foxborough, MA |
| 8 | Sun Nov 1 | atBills | L21-24 | 2-5 | .286 | Highmark Stadium · Orchard Park, NY |
| 9 | Mon Nov 9 | atJets | W30-27 | 3-5 | .375 | MetLife Stadium · East Rutherford, NJ |
| 10 | Sun Nov 15 | vsRavens | W23-17 | 4-5 | .444 | Gillette Stadium · Foxborough, MA |
| 11 | Sun Nov 22 | atTexans | L20-27 | 4-6 | .400 | NRG Stadium · Houston, TX |
| 12 | Sun Nov 29 | vsCardinals | W20-17 | 5-6 | .455 | Gillette Stadium · Foxborough, MA |
| 13 | Sun Dec 6 | atChargers | W45-0 | 6-6 | .500 | SoFi Stadium · Inglewood, CA |
| 14 | Thu Dec 10 | atRams | L3-24 | 6-7 | .462 | SoFi Stadium · Inglewood, CA |
| 15 | Sun Dec 20 | atDolphins | L12-22 | 6-8 | .429 | Hard Rock Stadium · Miami Gardens, FL |
| 16 | Mon Dec 28 | vsBills | L9-38 | 6-9 | .400 | Gillette Stadium · Foxborough, MA |
| 17 | Sun Jan 3 | vsJets | W28-14 | 7-9 | .438 | Gillette Stadium · Foxborough, MA |
