| 1 | Sun Sep 10 | vs Eagles | L20-25 | 0-1 | .000 | Gillette Stadium · Foxborough, MA |
| 2 | Sun Sep 17 | vs Dolphins | L17-24 | 0-2 | .000 | Gillette Stadium · Foxborough, MA |
| 3 | Sun Sep 24 | at Jets | W15-10 | 1-2 | .333 | MetLife Stadium · East Rutherford, NJ |
| 4 | Sun Oct 1 | at Cowboys | L3-38 | 1-3 | .250 | AT&T Stadium · Arlington, TX |
| 5 | Sun Oct 8 | vs Saints | L0-34 | 1-4 | .200 | Gillette Stadium · Foxborough, MA |
| 6 | Sun Oct 15 | at Raiders | L17-21 | 1-5 | .167 | Allegiant Stadium · Las Vegas, NV |
| 7 | Sun Oct 22 | vs Bills | W29-25 | 2-5 | .286 | Gillette Stadium · Foxborough, MA |
| 8 | Sun Oct 29 | atDolphins | L17-31 | 2-6 | .250 | Hard Rock Stadium · Miami Gardens, FL |
| 9 | Sun Nov 5 | vs Commanders | L17-20 | 2-7 | .222 | Gillette Stadium · Foxborough, MA |
| 10 | Sun Nov 12 | vs Colts | L6-10 | 2-8 | .200 | Gillette Stadium · Foxborough, MA |
| 11 | -- BYE WEEK -- |
| 12 | Sun Nov 26 | at Giants | L7-10 | 2-9 | .182 | MetLife Stadium · East Rutherford, NJ |
| 13 | Sun Dec 3 | vs Chargers | L0-6 | 2-10 | .167 | Gillette Stadium · Foxborough, MA |
| 14 | Thu Dec 7 | at Steelers | W21-18 | 3-10 | .231 | Acrisure Stadium · Pittsburgh, PA |
| 15 | Sun Dec 17 | vs Chiefs | L17-27 | 3-11 | .214 | Gillette Stadium · Foxborough, MA |
| 16 | Sun Dec 24 | at Broncos | W26-23 | 4-11 | .267 | Empower Field at Mile High · Denver, CO |
| 17 | Sun Dec 31 | atBills | L21-27 | 4-12 | .250 | Highmark Stadium · Orchard Park, NY |
| 18 | Sun Jan 7 | vsJets | L3-17 | 4-13 | .235 | Gillette Stadium · Foxborough, MA |
