| 1 | Sun Sep 8 | at Browns | W43-13 | 1-0 | 1.000 | FirstEnergy Stadium · Cleveland, OH |
| 2 | Sun Sep 15 | vs Colts | L17-19 | 1-1 | .500 | Nissan Stadium · Nashville, TN |
| 3 | Thu Sep 19 | at Jaguars | L7-20 | 1-2 | .333 | TIAA Bank Field · Jacksonville, FL |
| 4 | Sun Sep 29 | at Falcons | W24-10 | 2-2 | .500 | Mercedes-Benz Stadium · Atlanta, GA |
| 5 | Sun Oct 6 | vs Bills | L7-14 | 2-3 | .400 | Nissan Stadium · Nashville, TN |
| 6 | Sun Oct 13 | at Broncos | L0-16 | 2-4 | .333 | Empower Field at Mile High · Denver, CO |
| 7 | Sun Oct 20 | vs Chargers | W23-20 | 3-4 | .429 | Nissan Stadium · Nashville, TN |
| 8 | Sun Oct 27 | vs Buccaneers | W27-23 | 4-4 | .500 | Nissan Stadium · Nashville, TN |
| 9 | Sun Nov 3 | at Panthers | L20-30 | 4-5 | .444 | Bank of America Stadium · Charlotte, NC |
| 10 | Sun Nov 10 | vs Chiefs | W35-32 | 5-5 | .500 | Nissan Stadium · Nashville, TN |
| 11 | -- BYE WEEK -- |
| 12 | Sun Nov 24 | vsJaguars | W42-20 | 6-5 | .545 | Nissan Stadium · Nashville, TN |
| 13 | Sun Dec 1 | atColts | W31-17 | 7-5 | .583 | Lucas Oil Stadium · Indianapolis, IN |
| 14 | Sun Dec 8 | at Raiders | W42-21 | 8-5 | .615 | Allegiant Stadium · Las Vegas, NV |
| 15 | Sun Dec 15 | vs Texans | L21-24 | 8-6 | .571 | Nissan Stadium · Nashville, TN |
| 16 | Sun Dec 22 | vs Saints | L28-38 | 8-7 | .533 | Nissan Stadium · Nashville, TN |
| 17 | Sun Dec 29 | atTexans | W35-14 | 9-7 | .563 | NRG Stadium · Houston, TX |
| WC | Sat Jan 4 | at Patriots | W20-13 | 9-7 | .563 | Gillette Stadium · Foxborough, MA |
| DIV | Sat Jan 11 | at Ravens | W28-12 | 9-7 | .563 | M&T Bank Stadium · Baltimore, MD |
| CONF | Sun Jan 19 | atChiefs | L24-35 | 9-7 | .563 | Arrowhead Stadium · Kansas City, MO |
