| 1 | Sun Sep 8 | at Bears | L17-24 | 0-1 | .000 | Soldier Field · Chicago, IL |
| 2 | Sun Sep 15 | vs Jets | L17-24 | 0-2 | .000 | Nissan Stadium · Nashville, TN |
| 3 | Sun Sep 22 | vs Packers | L14-30 | 0-3 | .000 | Nissan Stadium · Nashville, TN |
| 4 | Mon Sep 30 | at Dolphins | W31-12 | 1-3 | .250 | Hard Rock Stadium · Miami Gardens, FL |
| 5 | -- BYE WEEK -- |
| 6 | Sun Oct 13 | vs Colts | L17-20 | 1-4 | .200 | Nissan Stadium · Nashville, TN |
| 7 | Sun Oct 20 | at Bills | L10-34 | 1-5 | .167 | Highmark Stadium · Orchard Park, NY |
| 8 | Sun Oct 27 | at Lions | L14-52 | 1-6 | .143 | Ford Field · Detroit, MI |
| 9 | Sun Nov 3 | vs Patriots | W20-17 (OT) | 2-6 | .250 | Nissan Stadium · Nashville, TN |
| 10 | Sun Nov 10 | at Chargers | L17-27 | 2-7 | .222 | SoFi Stadium · Inglewood, CA |
| 11 | Sun Nov 17 | vs Vikings | L13-23 | 2-8 | .200 | Nissan Stadium · Nashville, TN |
| 12 | Sun Nov 24 | at Texans | W32-27 | 3-8 | .273 | NRG Stadium · Houston, TX |
| 13 | Sun Dec 1 | at Commanders | L19-42 | 3-9 | .250 | FedEx Field · North Englewood, MD |
| 14 | Sun Dec 8 | vs Jaguars | L6-10 | 3-10 | .231 | Nissan Stadium · Nashville, TN |
| 15 | Sun Dec 15 | vs Bengals | L27-37 | 3-11 | .214 | Nissan Stadium · Nashville, TN |
| 16 | Sun Dec 22 | atColts | L30-38 | 3-12 | .200 | Lucas Oil Stadium · Indianapolis, IN |
| 17 | Sun Dec 29 | atJaguars | L13-20 | 3-13 | .188 | TIAA Bank Field · Jacksonville, FL |
| 18 | Sun Jan 5 | vsTexans | L14-23 | 3-14 | .176 | Nissan Stadium · Nashville, TN |
