| 1 | Sun Sep 11 | vs Giants | L20-21 | 0-1 | .000 | Nissan Stadium · Nashville, TN |
| 2 | Mon Sep 19 | atBills | L7-41 | 0-2 | .000 | Highmark Stadium · Orchard Park, NY |
| 3 | Sun Sep 25 | vsRaiders | W24-22 | 1-2 | .333 | Nissan Stadium · Nashville, TN |
| 4 | Sun Oct 2 | atColts | W24-17 | 2-2 | .500 | Lucas Oil Stadium · Indianapolis, IN |
| 5 | Sun Oct 9 | atCommanders | W21-17 | 3-2 | .600 | FedEx Field · North Englewood, MD |
| --bye week-- |
| 7 | Sun Oct 23 | vsColts | W19-10 | 4-2 | .667 | Nissan Stadium · Nashville, TN |
| 8 | Sun Oct 30 | atTexans | W17-10 | 5-2 | .714 | NRG Stadium · Houston, TX |
| 9 | Sun Nov 6 | atChiefs | L17-20 (OT) | 5-3 | .625 | Arrowhead Stadium · Kansas City, MO |
| 10 | Sun Nov 13 | vsBroncos | W17-10 | 6-3 | .667 | Nissan Stadium · Nashville, TN |
| 11 | Thu Nov 17 | atPackers | W27-17 | 7-3 | .700 | Lambeau Field · Green Bay, WI |
| 12 | Sun Nov 27 | vsBengals | L16-20 | 7-4 | .636 | Nissan Stadium · Nashville, TN |
| 13 | Sun Dec 4 | atEagles | L10-35 | 7-5 | .583 | Lincoln Financial Field · Philadelphia, PA |
| 14 | Sun Dec 11 | vsJaguars | L22-36 | 7-6 | .538 | Nissan Stadium · Nashville, TN |
| 15 | Sun Dec 18 | atChargers | L14-17 | 7-7 | .500 | SoFi Stadium · Inglewood, CA |
| 16 | Sat Dec 24 | vsTexans | L14-19 | 7-8 | .467 | Nissan Stadium · Nashville, TN |
| 17 | Thu Dec 29 | vsCowboys | L13-27 | 7-9 | .438 | Nissan Stadium · Nashville, TN |
| 18 | Sat Jan 7 | atJaguars | L16-20 | 7-10 | .412 | TIAA Bank Field · Jacksonville, FL |
