| 1 | Sun Sep 10 | at Saints | L15-16 | 0-1 | .000 | Caesars Superdome · New Orleans, LA |
| 2 | Sun Sep 17 | vs Chargers | W27-24 (OT) | 1-1 | .500 | Nissan Stadium · Nashville, TN |
| 3 | Sun Sep 24 | at Browns | L3-27 | 1-2 | .333 | FirstEnergy Stadium · Cleveland, OH |
| 4 | Sun Oct 1 | vs Bengals | W27-3 | 2-2 | .500 | Nissan Stadium · Nashville, TN |
| 5 | Sun Oct 8 | at Colts | L16-23 | 2-3 | .400 | Lucas Oil Stadium · Indianapolis, IN |
| 6 | Sun Oct 15 | vs Ravens | L16-24 | 2-4 | .333 | Tottenham Hotspur Stadium · London, England |
| 7 | -- BYE WEEK -- |
| 8 | Sun Oct 29 | vs Falcons | W28-23 | 3-4 | .429 | Nissan Stadium · Nashville, TN |
| 9 | Thu Nov 2 | at Steelers | L16-20 | 3-5 | .375 | Acrisure Stadium · Pittsburgh, PA |
| 10 | Sun Nov 12 | at Buccaneers | L6-20 | 3-6 | .333 | Raymond James Stadium · Tampa, FL |
| 11 | Sun Nov 19 | at Jaguars | L14-34 | 3-7 | .300 | TIAA Bank Field · Jacksonville, FL |
| 12 | Sun Nov 26 | vs Panthers | W17-10 | 4-7 | .364 | Nissan Stadium · Nashville, TN |
| 13 | Sun Dec 3 | vsColts | L28-31 (OT) | 4-8 | .333 | Nissan Stadium · Nashville, TN |
| 14 | Mon Dec 11 | at Dolphins | W28-27 | 5-8 | .385 | Hard Rock Stadium · Miami Gardens, FL |
| 15 | Sun Dec 17 | vs Texans | L16-19 (OT) | 5-9 | .357 | Nissan Stadium · Nashville, TN |
| 16 | Sun Dec 24 | vs Seahawks | L17-20 | 5-10 | .333 | Nissan Stadium · Nashville, TN |
| 17 | Sun Dec 31 | atTexans | L3-26 | 5-11 | .313 | NRG Stadium · Houston, TX |
| 18 | Sun Jan 7 | vsJaguars | W28-20 | 6-11 | .353 | Nissan Stadium · Nashville, TN |
