| 1 | Sun Sep 12 | vs Cardinals | L13-38 | 0-1 | .000 | Nissan Stadium · Nashville, TN |
| 2 | Sun Sep 19 | atSeahawks | W33-30 (OT) | 1-1 | .500 | Lumen Field · Seattle, WA |
| 3 | Sun Sep 26 | vsColts | W25-16 | 2-1 | .667 | Nissan Stadium · Nashville, TN |
| 4 | Sun Oct 3 | atJets | L24-27 (OT) | 2-2 | .500 | MetLife Stadium · East Rutherford, NJ |
| 5 | Sun Oct 10 | atJaguars | W37-19 | 3-2 | .600 | TIAA Bank Field · Jacksonville, FL |
| 6 | Mon Oct 18 | vsBills | W34-31 | 4-2 | .667 | Nissan Stadium · Nashville, TN |
| 7 | Sun Oct 24 | vsChiefs | W27-3 | 5-2 | .714 | Nissan Stadium · Nashville, TN |
| 8 | Sun Oct 31 | atColts | W34-31 (OT) | 6-2 | .750 | Lucas Oil Stadium · Indianapolis, IN |
| 9 | Sun Nov 7 | atRams | W28-16 | 7-2 | .778 | SoFi Stadium · Inglewood, CA |
| 10 | Sun Nov 14 | vsSaints | W23-21 | 8-2 | .800 | Nissan Stadium · Nashville, TN |
| 11 | Sun Nov 21 | vsTexans | L13-22 | 8-3 | .727 | Nissan Stadium · Nashville, TN |
| 12 | Sun Nov 28 | atPatriots | L13-36 | 8-4 | .667 | Gillette Stadium · Foxborough, MA |
| --bye week-- |
| 14 | Sun Dec 12 | vsJaguars | W20-0 | 9-4 | .692 | Nissan Stadium · Nashville, TN |
| 15 | Sun Dec 19 | atSteelers | L13-19 | 9-5 | .643 | Acrisure Stadium · Pittsburgh, PA |
| 16 | Thu Dec 23 | vs49ers | W20-17 | 10-5 | .667 | Nissan Stadium · Nashville, TN |
| 17 | Sun Jan 2 | vsDolphins | W34-3 | 11-5 | .688 | Nissan Stadium · Nashville, TN |
| 18 | Sun Jan 9 | atTexans | W28-25 | 12-5 | .706 | NRG Stadium · Houston, TX |
| DIV | Sat Jan 22 | vsBengals | L16-19 | 12-5 | .706 | Nissan Stadium · Nashville, TN |
