| 4 | Sun Sep 28 | at Texans | 1:00 PM | 0-3 | .000 | NRG Stadium · Houston, TX |
| 5 | Sun Oct 5 | atCardinals | 4:05 PM | 2-2 | .500 | State Farm Stadium · Glendale, AZ |
| 6 | Sun Oct 12 | atRaiders | 4:05 PM | 1-2 | .333 | Allegiant Stadium · Las Vegas, NV |
| 7 | Sun Oct 19 | vsPatriots | 1:00 PM | 1-2 | .333 | Nissan Stadium · Nashville, TN |
| 8 | Sun Oct 26 | atColts | 4:25 PM | 3-0 | 1.000 | Lucas Oil Stadium · Indianapolis, IN |
| 9 | Sun Nov 2 | vsChargers | 1:00 PM | 3-0 | 1.000 | Nissan Stadium · Nashville, TN |
| --bye week-- |
| 11 | Sun Nov 16 | vsTexans | 1:00 PM | 0-3 | .000 | Nissan Stadium · Nashville, TN |
| 12 | Sun Nov 23 | vsSeahawks | 1:00 PM | 3-1 | .750 | Nissan Stadium · Nashville, TN |
| 13 | Sun Nov 30 | vsJaguars | 1:00 PM | 2-1 | .667 | Nissan Stadium · Nashville, TN |
| 14 | Sun Dec 7 | atBrowns | 1:00 PM | 1-2 | .333 | FirstEnergy Stadium · Cleveland, OH |
| 15 | Sun Dec 14 | at49ers | 4:25 PM | 3-0 | 1.000 | Levi's® Stadium · Santa Clara, CA |
| 16 | Sun Dec 21 | vsChiefs | 1:00 PM | 1-2 | .333 | Nissan Stadium · Nashville, TN |
| 17 | Sun Dec 28 | vsSaints | 1:00 PM | 0-3 | .000 | Nissan Stadium · Nashville, TN |
| 18 | TBD | atJaguars | TBD | 2-1 | .667 | TIAA Bank Field · Jacksonville, FL |
