| 1 | Mon Sep 14 | at Broncos | W16-14 | 1-0 | 1.000 | Empower Field at Mile High · Denver, CO |
| 2 | Sun Sep 20 | vsJaguars | W33-30 | 2-0 | 1.000 | Nissan Stadium · Nashville, TN |
| 3 | Sun Sep 27 | atVikings | W31-30 | 3-0 | 1.000 | U.S. Bank Stadium · Minneapolis, MN |
| --bye week-- |
| 5 | Tue Oct 13 | vsBills | W42-16 | 4-0 | 1.000 | Nissan Stadium · Nashville, TN |
| 6 | Sun Oct 18 | vsTexans | W42-36 (OT) | 5-0 | 1.000 | Nissan Stadium · Nashville, TN |
| 7 | Sun Oct 25 | vsSteelers | L24-27 | 5-1 | .833 | Nissan Stadium · Nashville, TN |
| 8 | Sun Nov 1 | atBengals | L20-31 | 5-2 | .714 | Paycor Stadium · Cincinnati, OH |
| 9 | Sun Nov 8 | vsBears | W24-17 | 6-2 | .750 | Nissan Stadium · Nashville, TN |
| 10 | Thu Nov 12 | vsColts | L17-34 | 6-3 | .667 | Nissan Stadium · Nashville, TN |
| 11 | Sun Nov 22 | atRavens | W30-24 (OT) | 7-3 | .700 | M&T Bank Stadium · Baltimore, MD |
| 12 | Sun Nov 29 | atColts | W45-26 | 8-3 | .727 | Lucas Oil Stadium · Indianapolis, IN |
| 13 | Sun Dec 6 | vsBrowns | L35-41 | 8-4 | .667 | Nissan Stadium · Nashville, TN |
| 14 | Sun Dec 13 | atJaguars | W31-10 | 9-4 | .692 | TIAA Bank Field · Jacksonville, FL |
| 15 | Sun Dec 20 | vsLions | W46-25 | 10-4 | .714 | Nissan Stadium · Nashville, TN |
| 16 | Sun Dec 27 | atPackers | L14-40 | 10-5 | .667 | Lambeau Field · Green Bay, WI |
| 17 | Sun Jan 3 | atTexans | W41-38 | 11-5 | .688 | NRG Stadium · Houston, TX |
| WC | Sun Jan 10 | vsRavens | L13-20 | 11-5 | .688 | Nissan Stadium · Nashville, TN |
