| 1 | Thu Oct 27 | vs Celtics | W105-99 | 1-0 | 1.000 | United Center · Chicago, IL |
| 2 | Sat Oct 29 | vs Pacers | W118-101 | 2-0 | 1.000 | United Center · Chicago, IL |
| 3 | Mon Oct 31 | at Nets | W118-88 | 3-0 | 1.000 | Barclays Center · Brooklyn, NY |
| 4 | Wed Nov 2 | atCeltics | L100-107 | 3-1 | .750 | TD Garden · Boston, MA |
| 5 | Fri Nov 4 | vs Knicks | L104-117 | 3-2 | .600 | United Center · Chicago, IL |
| 6 | Sat Nov 5 | atPacers | L94-111 | 3-3 | .500 | Gainbridge Fieldhouse · Indianapolis, IN |
| 7 | Mon Nov 7 | vs Magic | W112-80 | 4-3 | .571 | United Center · Chicago, IL |
| 8 | Wed Nov 9 | at Hawks | L107-115 | 4-4 | .500 | State Farm Arena · Atlanta, GA |
| 9 | Thu Nov 10 | at Heat | W98-95 | 5-4 | .556 | FTX Arena · Miami, FL |
| 10 | Sat Nov 12 | vs Wizards | W106-95 | 6-4 | .600 | United Center · Chicago, IL |
| 11 | Tue Nov 15 | at Blazers | W113-88 | 7-4 | .636 | Moda Center · Portland, OR |
| 12 | Thu Nov 17 | at Jazz | W85-77 | 8-4 | .667 | Vivint Arena · Salt Lake City, UT |
| 13 | Sat Nov 19 | at Clippers | L95-102 | 8-5 | .615 | Crypto.com Arena · Los Angeles, CA |
| 14 | Sun Nov 20 | at Lakers | W118-110 | 9-5 | .643 | Crypto.com Arena · Los Angeles, CA |
| 15 | Tue Nov 22 | at Nuggets | L107-110 | 9-6 | .600 | Ball Arena · Denver, CO |
| 16 | Fri Nov 25 | at 76ers | W105-89 | 10-6 | .625 | Wells Fargo Center · Philadelphia, PA |
| 17 | Wed Nov 30 | vsLakers | L90-96 | 10-7 | .588 | United Center · Chicago, IL |
| 18 | Fri Dec 2 | vs Cavaliers | W111-105 | 11-7 | .611 | United Center · Chicago, IL |
| 19 | Sat Dec 3 | at Mavericks | L82-107 | 11-8 | .579 | American Airlines Center · Dallas, TX |
| 20 | Mon Dec 5 | vsBlazers | L110-112 | 11-9 | .550 | United Center · Chicago, IL |
| 21 | Tue Dec 6 | at Pistons | L91-102 | 11-10 | .524 | Little Caesars Arena · Detroit, MI |
| 22 | Thu Dec 8 | vs Spurs | W95-91 | 12-10 | .545 | United Center · Chicago, IL |
| 23 | Sat Dec 10 | vsHeat | W105-100 | 13-10 | .565 | United Center · Chicago, IL |
| 24 | Tue Dec 13 | vs T-wolves | L94-99 | 13-11 | .542 | United Center · Chicago, IL |
| 25 | Thu Dec 15 | at Bucks | L97-108 | 13-12 | .520 | Fiserv Forum · Milwaukee, WI |
| 26 | Fri Dec 16 | vsBucks | L69-95 | 13-13 | .500 | United Center · Chicago, IL |
| 27 | Mon Dec 19 | vsPistons | W113-82 | 14-13 | .519 | United Center · Chicago, IL |
| 28 | Wed Dec 21 | vsWizards | L97-107 | 14-14 | .500 | United Center · Chicago, IL |
| 29 | Fri Dec 23 | at Hornets | L91-103 | 14-15 | .483 | Spectrum Center · Charlotte, NC |
| 30 | Sun Dec 25 | atSpurs | L100-119 | 14-16 | .467 | AT&T Center · San Antonio, TX |
| 31 | Mon Dec 26 | vsPacers | W90-85 | 15-16 | .484 | United Center · Chicago, IL |
| 32 | Wed Dec 28 | vsNets | W101-99 | 16-16 | .500 | United Center · Chicago, IL |
| 33 | Fri Dec 30 | atPacers | L101-111 | 16-17 | .485 | Gainbridge Fieldhouse · Indianapolis, IN |
| 34 | Sat Dec 31 | vsBucks | L96-116 | 16-18 | .471 | United Center · Chicago, IL |
| 35 | Mon Jan 2 | vsHornets | W118-111 | 17-18 | .486 | United Center · Chicago, IL |
| 36 | Wed Jan 4 | atCavaliers | W106-94 | 18-18 | .500 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 37 | Sat Jan 7 | vs Raptors | W123-118 (OT) | 19-18 | .514 | United Center · Chicago, IL |
| 38 | Mon Jan 9 | vs Thunder | L94-109 | 19-19 | .500 | United Center · Chicago, IL |
| 39 | Tue Jan 10 | atWizards | L99-101 | 19-20 | .487 | Capital One Arena · Washington, D.C. |
| 40 | Thu Jan 12 | atKnicks | L89-104 | 19-21 | .475 | Madison Square Garden · Manhattan, NY |
| 41 | Sat Jan 14 | vs Pelicans | W107-99 | 20-21 | .488 | United Center · Chicago, IL |
| 42 | Sun Jan 15 | at Grizzlies | W108-104 | 21-21 | .500 | FedExForum · Memphis, TN |
| 43 | Tue Jan 17 | vsMavericks | L98-99 | 21-22 | .488 | United Center · Chicago, IL |
| 44 | Fri Jan 20 | atHawks | L93-102 | 21-23 | .477 | State Farm Arena · Atlanta, GA |
| 45 | Sat Jan 21 | vs Kings | W102-99 | 22-23 | .489 | United Center · Chicago, IL |
| 46 | Tue Jan 24 | atMagic | W100-92 | 23-23 | .500 | Amway Center · Orlando, FL |
| 47 | Wed Jan 25 | vsHawks | L114-119 | 23-24 | .489 | United Center · Chicago, IL |
| 48 | Fri Jan 27 | vsHeat | L88-100 | 23-25 | .479 | United Center · Chicago, IL |
| 49 | Sun Jan 29 | vs76ers | W121-108 | 24-25 | .490 | United Center · Chicago, IL |
| 50 | Wed Feb 1 | atThunder | W128-100 | 25-25 | .500 | Paycom Center · Oklahoma City, OK |
| 51 | Fri Feb 3 | at Rockets | L117-121 (OT) | 25-26 | .490 | Toyota Center · Houston, TX |
| 52 | Mon Feb 6 | atKings | W112-107 | 26-26 | .500 | Golden 1 Center · Sacramento, CA |
| 53 | Wed Feb 8 | at Warriors | L92-123 | 26-27 | .491 | Chase Center · San Francisco, CA |
| 54 | Fri Feb 10 | at Suns | L97-115 | 26-28 | .481 | Footprint Center · Phoenix, AZ |
| 55 | Sun Feb 12 | atT-wolves | L89-117 | 26-29 | .473 | Target Center · Minneapolis, MN |
| 56 | Tue Feb 14 | vsRaptors | W105-94 | 27-29 | .482 | United Center · Chicago, IL |
| 57 | Thu Feb 16 | vsCeltics | W104-103 | 28-29 | .491 | United Center · Chicago, IL |
| 58 | Fri Feb 24 | vsSuns | W128-121 (OT) | 29-29 | .500 | United Center · Chicago, IL |
| 59 | Sat Feb 25 | atCavaliers | W117-99 | 30-29 | .508 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 60 | Tue Feb 28 | vsNuggets | L107-125 | 30-30 | .500 | United Center · Chicago, IL |
| 61 | Thu Mar 2 | vsWarriors | W94-87 | 31-30 | .508 | United Center · Chicago, IL |
| 62 | Sat Mar 4 | vsClippers | L91-101 | 31-31 | .500 | United Center · Chicago, IL |
| 63 | Mon Mar 6 | atPistons | L95-109 | 31-32 | .492 | Little Caesars Arena · Detroit, MI |
| 64 | Wed Mar 8 | atMagic | L91-98 | 31-33 | .484 | Amway Center · Orlando, FL |
| 65 | Fri Mar 10 | vsRockets | L94-115 | 31-34 | .477 | United Center · Chicago, IL |
| 66 | Sun Mar 12 | atCeltics | L80-100 | 31-35 | .470 | TD Garden · Boston, MA |
| 67 | Mon Mar 13 | atHornets | W115-109 | 32-35 | .478 | Spectrum Center · Charlotte, NC |
| 68 | Wed Mar 15 | vsGrizzlies | L91-98 | 32-36 | .471 | United Center · Chicago, IL |
| 69 | Fri Mar 17 | atWizards | L107-112 | 32-37 | .464 | Capital One Arena · Washington, D.C. |
| 70 | Sat Mar 18 | vsJazz | W95-86 | 33-37 | .471 | United Center · Chicago, IL |
| 71 | Tue Mar 21 | atRaptors | L120-122 (OT) | 33-38 | .465 | Scotiabank Arena · Toronto, ON |
| 72 | Wed Mar 22 | vsPistons | W117-95 | 34-38 | .472 | United Center · Chicago, IL |
| 73 | Fri Mar 24 | vs76ers | L107-117 | 34-39 | .466 | United Center · Chicago, IL |
| 74 | Sun Mar 26 | atBucks | W109-94 | 35-39 | .473 | Fiserv Forum · Milwaukee, WI |
| 75 | Thu Mar 30 | vsCavaliers | W99-93 | 36-39 | .480 | United Center · Chicago, IL |
| 76 | Sat Apr 1 | vsHawks | W106-104 | 37-39 | .487 | United Center · Chicago, IL |
| 77 | Sun Apr 2 | atPelicans | W117-110 | 38-39 | .494 | Smoothie King Center · New Orleans, LA |
| 78 | Tue Apr 4 | atKnicks | L91-100 | 38-40 | .487 | Madison Square Garden · Manhattan, NY |
| 79 | Thu Apr 6 | at76ers | W102-90 | 39-40 | .494 | Wells Fargo Center · Philadelphia, PA |
| 80 | Sat Apr 8 | atNets | L106-107 | 39-41 | .487 | Barclays Center · Brooklyn, NY |
| 81 | Mon Apr 10 | vsMagic | W122-75 | 40-41 | .494 | United Center · Chicago, IL |
| 82 | Wed Apr 12 | vsNets | W112-73 | 41-41 | .500 | United Center · Chicago, IL |
| 1 | Sun Apr 16 | atCeltics | W106-102 | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Tue Apr 18 | atCeltics | W111-97 | 2-0 | 1.000 | TD Garden · Boston, MA |
| 3 | Fri Apr 21 | vsCeltics | L87-104 | 2-1 | .667 | United Center · Chicago, IL |
| 4 | Sun Apr 23 | vsCeltics | L95-104 | 2-2 | .500 | United Center · Chicago, IL |
| 5 | Wed Apr 26 | atCeltics | L97-108 | 2-3 | .400 | TD Garden · Boston, MA |
| 6 | Fri Apr 28 | vsCeltics | L83-105 | 2-4 | .333 | United Center · Chicago, IL |
