| 1 | Thu Oct 19 | at Raptors | L100-117 | 0-1 | .000 | Scotiabank Arena · Toronto, ON |
| 2 | Sat Oct 21 | vs Spurs | L77-87 | 0-2 | .000 | United Center · Chicago, IL |
| 3 | Tue Oct 24 | at Cavaliers | L112-119 | 0-3 | .000 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 4 | Thu Oct 26 | vs Hawks | W91-86 | 1-3 | .250 | United Center · Chicago, IL |
| 5 | Sat Oct 28 | vs Thunder | L69-101 | 1-4 | .200 | United Center · Chicago, IL |
| 6 | Wed Nov 1 | at Heat | L91-97 | 1-5 | .167 | FTX Arena · Miami, FL |
| 7 | Fri Nov 3 | at Magic | W105-83 | 2-5 | .286 | Amway Center · Orlando, FL |
| 8 | Sat Nov 4 | vs Pelicans | L90-96 (OT) | 2-6 | .250 | United Center · Chicago, IL |
| 9 | Tue Nov 7 | atRaptors | L114-119 | 2-7 | .222 | Scotiabank Arena · Toronto, ON |
| 10 | Fri Nov 10 | vs Pacers | L87-105 | 2-8 | .200 | United Center · Chicago, IL |
| 11 | Sat Nov 11 | atSpurs | L94-133 | 2-9 | .182 | AT&T Center · San Antonio, TX |
| 12 | Wed Nov 15 | atThunder | L79-92 | 2-10 | .167 | Paycom Center · Oklahoma City, OK |
| 13 | Fri Nov 17 | vs Hornets | W123-120 | 3-10 | .231 | United Center · Chicago, IL |
| 14 | Sun Nov 19 | at Suns | L105-113 | 3-11 | .214 | Footprint Center · Phoenix, AZ |
| 15 | Tue Nov 21 | at Lakers | L94-103 | 3-12 | .200 | Crypto.com Arena · Los Angeles, CA |
| 16 | Wed Nov 22 | at Jazz | L80-110 | 3-13 | .188 | Vivint Arena · Salt Lake City, UT |
| 17 | Fri Nov 24 | at Warriors | L94-143 | 3-14 | .176 | Chase Center · San Francisco, CA |
| 18 | Sun Nov 26 | vsHeat | L93-100 | 3-15 | .167 | United Center · Chicago, IL |
| 19 | Tue Nov 28 | vsSuns | L99-104 | 3-16 | .158 | United Center · Chicago, IL |
| 20 | Thu Nov 30 | at Nuggets | L110-111 | 3-17 | .150 | Ball Arena · Denver, CO |
| 21 | Fri Dec 1 | vs Kings | L106-107 | 3-18 | .143 | United Center · Chicago, IL |
| 22 | Mon Dec 4 | vsCavaliers | L91-113 | 3-19 | .136 | United Center · Chicago, IL |
| 23 | Wed Dec 6 | atPacers | L96-98 | 3-20 | .130 | Gainbridge Fieldhouse · Indianapolis, IN |
| 24 | Fri Dec 8 | atHornets | W119-111 (OT) | 4-20 | .167 | Spectrum Center · Charlotte, NC |
| 25 | Sat Dec 9 | vs Knicks | W104-102 | 5-20 | .200 | United Center · Chicago, IL |
| 26 | Mon Dec 11 | vs Celtics | W108-85 | 6-20 | .231 | United Center · Chicago, IL |
| 27 | Wed Dec 13 | vsJazz | W103-100 | 7-20 | .259 | United Center · Chicago, IL |
| 28 | Fri Dec 15 | at Bucks | W115-109 | 8-20 | .286 | Fiserv Forum · Milwaukee, WI |
| 29 | Mon Dec 18 | vs 76ers | W117-115 | 9-20 | .310 | United Center · Chicago, IL |
| 30 | Wed Dec 20 | vsMagic | W112-94 | 10-20 | .333 | United Center · Chicago, IL |
| 31 | Thu Dec 21 | atCavaliers | L112-115 | 10-21 | .323 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 32 | Sat Dec 23 | atCeltics | L92-117 | 10-22 | .313 | TD Garden · Boston, MA |
| 33 | Tue Dec 26 | atBucks | W115-106 | 11-22 | .333 | Fiserv Forum · Milwaukee, WI |
| 34 | Wed Dec 27 | vsKnicks | W92-87 | 12-22 | .353 | United Center · Chicago, IL |
| 35 | Fri Dec 29 | vsPacers | W119-107 | 13-22 | .371 | United Center · Chicago, IL |
| 36 | Sun Dec 31 | at Wizards | L110-114 | 13-23 | .361 | Capital One Arena · Washington, D.C. |
| 37 | Mon Jan 1 | vs Blazers | L120-124 (OT) | 13-24 | .351 | United Center · Chicago, IL |
| 38 | Wed Jan 3 | vsRaptors | L115-124 | 13-25 | .342 | United Center · Chicago, IL |
| 39 | Fri Jan 5 | at Mavericks | W127-124 | 14-25 | .359 | American Airlines Center · Dallas, TX |
| 40 | Sat Jan 6 | atPacers | L86-125 | 14-26 | .350 | Gainbridge Fieldhouse · Indianapolis, IN |
| 41 | Mon Jan 8 | vs Rockets | L107-116 | 14-27 | .341 | United Center · Chicago, IL |
| 42 | Wed Jan 10 | atKnicks | W122-119 (2OT) | 15-27 | .357 | Madison Square Garden · Manhattan, NY |
| 43 | Sat Jan 13 | vs Pistons | W107-105 | 16-27 | .372 | United Center · Chicago, IL |
| 44 | Mon Jan 15 | vsHeat | W119-111 | 17-27 | .386 | United Center · Chicago, IL |
| 45 | Wed Jan 17 | vsWarriors | L112-119 | 17-28 | .378 | United Center · Chicago, IL |
| 46 | Sat Jan 20 | atHawks | W113-97 | 18-28 | .391 | State Farm Arena · Atlanta, GA |
| 47 | Mon Jan 22 | atPelicans | L128-132 (2OT) | 18-29 | .383 | Smoothie King Center · New Orleans, LA |
| 48 | Wed Jan 24 | at76ers | L101-115 | 18-30 | .375 | Wells Fargo Center · Philadelphia, PA |
| 49 | Fri Jan 26 | vsLakers | L103-108 | 18-31 | .367 | United Center · Chicago, IL |
| 50 | Sun Jan 28 | vsBucks | L96-110 | 18-32 | .360 | United Center · Chicago, IL |
| 51 | Wed Jan 31 | atBlazers | L108-124 | 18-33 | .353 | Moda Center · Portland, OR |
| 52 | Sat Feb 3 | at Clippers | L103-113 | 18-34 | .346 | Crypto.com Arena · Los Angeles, CA |
| 53 | Mon Feb 5 | atKings | L98-104 | 18-35 | .340 | Golden 1 Center · Sacramento, CA |
| 54 | Fri Feb 9 | vs T-wolves | W114-113 | 19-35 | .352 | United Center · Chicago, IL |
| 55 | Sat Feb 10 | vsWizards | L90-101 | 19-36 | .345 | United Center · Chicago, IL |
| 56 | Mon Feb 12 | vsMagic | W105-101 | 20-36 | .357 | United Center · Chicago, IL |
| 57 | Wed Feb 14 | vsRaptors | L98-122 | 20-37 | .351 | United Center · Chicago, IL |
| 58 | Thu Feb 22 | vs76ers | L115-116 | 20-38 | .345 | United Center · Chicago, IL |
| 59 | Sat Feb 24 | atT-wolves | L104-122 | 20-39 | .339 | Target Center · Minneapolis, MN |
| 60 | Mon Feb 26 | at Nets | L87-104 | 20-40 | .333 | Barclays Center · Brooklyn, NY |
| 61 | Tue Feb 27 | atHornets | L103-118 | 20-41 | .328 | Spectrum Center · Charlotte, NC |
| 62 | Fri Mar 2 | vsMavericks | W108-100 | 21-41 | .339 | United Center · Chicago, IL |
| 63 | Mon Mar 5 | vsCeltics | L89-105 | 21-42 | .333 | United Center · Chicago, IL |
| 64 | Wed Mar 7 | vs Grizzlies | W119-110 | 22-42 | .344 | United Center · Chicago, IL |
| 65 | Fri Mar 9 | atPistons | L83-99 | 22-43 | .338 | Little Caesars Arena · Detroit, MI |
| 66 | Sun Mar 11 | atHawks | W129-122 | 23-43 | .348 | State Farm Arena · Atlanta, GA |
| 67 | Tue Mar 13 | vsClippers | L106-112 | 23-44 | .343 | United Center · Chicago, IL |
| 68 | Thu Mar 15 | atGrizzlies | W111-110 | 24-44 | .353 | FedExForum · Memphis, TN |
| 69 | Sat Mar 17 | vsCavaliers | L109-114 | 24-45 | .348 | United Center · Chicago, IL |
| 70 | Mon Mar 19 | atKnicks | L92-110 | 24-46 | .343 | Madison Square Garden · Manhattan, NY |
| 71 | Wed Mar 21 | vsNuggets | L102-135 | 24-47 | .338 | United Center · Chicago, IL |
| 72 | Fri Mar 23 | vsBucks | L105-118 | 24-48 | .333 | United Center · Chicago, IL |
| 73 | Sat Mar 24 | atPistons | L95-117 | 24-49 | .329 | Little Caesars Arena · Detroit, MI |
| 74 | Tue Mar 27 | atRockets | L86-118 | 24-50 | .324 | Toyota Center · Houston, TX |
| 75 | Thu Mar 29 | atHeat | L92-103 | 24-51 | .320 | FTX Arena · Miami, FL |
| 76 | Fri Mar 30 | atMagic | W90-82 | 25-51 | .329 | Amway Center · Orlando, FL |
| 77 | Sun Apr 1 | vsWizards | W113-94 | 26-51 | .338 | United Center · Chicago, IL |
| 78 | Tue Apr 3 | vsHornets | W120-114 | 27-51 | .346 | United Center · Chicago, IL |
| 79 | Fri Apr 6 | atCeltics | L104-111 | 27-52 | .342 | TD Garden · Boston, MA |
| 80 | Sat Apr 7 | vsNets | L96-124 | 27-53 | .338 | United Center · Chicago, IL |
| 81 | Mon Apr 9 | atNets | L105-114 | 27-54 | .333 | Barclays Center · Brooklyn, NY |
| 82 | Wed Apr 11 | vsPistons | L87-119 | 27-55 | .329 | United Center · Chicago, IL |
