| 1 | Wed Oct 19 | at Heat | W116-108 | 1-0 | 1.000 | FTX Arena · Miami, FL |
| 2 | Fri Oct 21 | at Wizards | L100-102 | 1-1 | .500 | Capital One Arena · Washington, D.C. |
| 3 | Sat Oct 22 | vs Cavaliers | L96-128 | 1-2 | .333 | United Center · Chicago, IL |
| 4 | Mon Oct 24 | vs Celtics | W120-102 | 2-2 | .500 | United Center · Chicago, IL |
| 5 | Wed Oct 26 | vs Pacers | W124-109 | 3-2 | .600 | United Center · Chicago, IL |
| 6 | Fri Oct 28 | at Spurs | L124-129 | 3-3 | .500 | AT&T Center · San Antonio, TX |
| 7 | Sat Oct 29 | vs 76ers | L109-114 | 3-4 | .429 | United Center · Chicago, IL |
| 8 | Tue Nov 1 | at Nets | W108-99 | 4-4 | .500 | Barclays Center · Brooklyn, NY |
| 9 | Wed Nov 2 | vs Hornets | W106-88 | 5-4 | .556 | United Center · Chicago, IL |
| 10 | Fri Nov 4 | atCeltics | L119-123 | 5-5 | .500 | TD Garden · Boston, MA |
| 11 | Sun Nov 6 | at Raptors | L104-113 | 5-6 | .455 | Scotiabank Arena · Toronto, ON |
| 12 | Mon Nov 7 | vsRaptors | W111-97 | 6-6 | .500 | United Center · Chicago, IL |
| 13 | Wed Nov 9 | vs Pelicans | L111-115 | 6-7 | .462 | United Center · Chicago, IL |
| 14 | Sun Nov 13 | vs Nuggets | L103-126 | 6-8 | .429 | United Center · Chicago, IL |
| 15 | Wed Nov 16 | atPelicans | L110-124 | 6-9 | .400 | Smoothie King Center · New Orleans, LA |
| 16 | Fri Nov 18 | vs Magic | L107-108 | 6-10 | .375 | United Center · Chicago, IL |
| 17 | Mon Nov 21 | vsCeltics | W121-107 | 7-10 | .412 | United Center · Chicago, IL |
| 18 | Wed Nov 23 | at Bucks | W118-113 | 8-10 | .444 | Fiserv Forum · Milwaukee, WI |
| 19 | Fri Nov 25 | at Thunder | L119-123 (OT) | 8-11 | .421 | Paycom Center · Oklahoma City, OK |
| 20 | Mon Nov 28 | at Jazz | W114-107 | 9-11 | .450 | Vivint Arena · Salt Lake City, UT |
| 21 | Wed Nov 30 | at Suns | L113-132 | 9-12 | .429 | Footprint Center · Phoenix, AZ |
| 22 | Fri Dec 2 | at Warriors | L111-119 | 9-13 | .409 | Chase Center · San Francisco, CA |
| 23 | Sun Dec 4 | at Kings | L101-110 | 9-14 | .391 | Golden 1 Center · Sacramento, CA |
| 24 | Wed Dec 7 | vsWizards | W115-111 | 10-14 | .417 | United Center · Chicago, IL |
| 25 | Sat Dec 10 | vs Mavericks | W144-115 | 11-14 | .440 | United Center · Chicago, IL |
| 26 | Sun Dec 11 | at Hawks | L122-123 (OT) | 11-15 | .423 | State Farm Arena · Atlanta, GA |
| 27 | Wed Dec 14 | vs Knicks | L120-128 (OT) | 11-16 | .407 | United Center · Chicago, IL |
| 28 | Fri Dec 16 | vsKnicks | L91-114 | 11-17 | .393 | United Center · Chicago, IL |
| 29 | Sun Dec 18 | at T-wolves | L126-150 | 11-18 | .379 | Target Center · Minneapolis, MN |
| 30 | Tue Dec 20 | atHeat | W113-103 | 12-18 | .400 | FTX Arena · Miami, FL |
| 31 | Wed Dec 21 | atHawks | W110-108 | 13-18 | .419 | State Farm Arena · Atlanta, GA |
| 32 | Fri Dec 23 | atKnicks | W118-117 | 14-18 | .438 | Madison Square Garden · Manhattan, NY |
| 33 | Mon Dec 26 | vs Rockets | L118-133 | 14-19 | .424 | United Center · Chicago, IL |
| 34 | Wed Dec 28 | vsBucks | W119-113 (OT) | 15-19 | .441 | United Center · Chicago, IL |
| 35 | Fri Dec 30 | vs Pistons | W132-118 | 16-19 | .457 | United Center · Chicago, IL |
| 36 | Sat Dec 31 | vsCavaliers | L102-103 | 16-20 | .444 | United Center · Chicago, IL |
| 37 | Mon Jan 2 | atCavaliers | L134-145 (OT) | 16-21 | .432 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 38 | Wed Jan 4 | vsNets | W121-112 | 17-21 | .447 | United Center · Chicago, IL |
| 39 | Fri Jan 6 | at76ers | W126-112 | 18-21 | .462 | Wells Fargo Center · Philadelphia, PA |
| 40 | Sat Jan 7 | vsJazz | W126-118 | 19-21 | .475 | United Center · Chicago, IL |
| 41 | Mon Jan 9 | atCeltics | L99-107 | 19-22 | .463 | TD Garden · Boston, MA |
| 42 | Wed Jan 11 | atWizards | L97-100 | 19-23 | .452 | Capital One Arena · Washington, D.C. |
| 43 | Fri Jan 13 | vsThunder | L110-124 | 19-24 | .442 | United Center · Chicago, IL |
| 44 | Sun Jan 15 | vsWarriors | W132-118 | 20-24 | .455 | United Center · Chicago, IL |
| 45 | Thu Jan 19 | atPistons | W126-108 | 21-24 | .467 | Little Caesars Arena · Detroit, MI |
| 46 | Mon Jan 23 | vsHawks | W111-100 | 22-24 | .478 | United Center · Chicago, IL |
| 47 | Tue Jan 24 | atPacers | L110-116 | 22-25 | .468 | Gainbridge Fieldhouse · Indianapolis, IN |
| 48 | Thu Jan 26 | atHornets | L96-111 | 22-26 | .458 | Spectrum Center · Charlotte, NC |
| 49 | Sat Jan 28 | atMagic | W128-109 | 23-26 | .469 | Amway Center · Orlando, FL |
| 50 | Tue Jan 31 | vs Clippers | L103-108 | 23-27 | .460 | United Center · Chicago, IL |
| 51 | Thu Feb 2 | vsHornets | W114-98 | 24-27 | .471 | United Center · Chicago, IL |
| 52 | Sat Feb 4 | vs Blazers | W129-121 | 25-27 | .481 | United Center · Chicago, IL |
| 53 | Mon Feb 6 | vsSpurs | W128-104 | 26-27 | .491 | United Center · Chicago, IL |
| 54 | Tue Feb 7 | at Grizzlies | L89-104 | 26-28 | .481 | FedExForum · Memphis, TN |
| 55 | Thu Feb 9 | atNets | L105-116 | 26-29 | .473 | Barclays Center · Brooklyn, NY |
| 56 | Sat Feb 11 | atCavaliers | L89-97 | 26-30 | .464 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 57 | Mon Feb 13 | vsMagic | L91-100 | 26-31 | .456 | United Center · Chicago, IL |
| 58 | Wed Feb 15 | atPacers | L113-117 | 26-32 | .448 | Gainbridge Fieldhouse · Indianapolis, IN |
| 59 | Thu Feb 16 | vsBucks | L100-112 | 26-33 | .441 | United Center · Chicago, IL |
| 60 | Fri Feb 24 | vsNets | W131-87 | 27-33 | .450 | United Center · Chicago, IL |
| 61 | Sun Feb 26 | vsWizards | W102-82 | 28-33 | .459 | United Center · Chicago, IL |
| 62 | Tue Feb 28 | atRaptors | L98-104 | 28-34 | .452 | Scotiabank Arena · Toronto, ON |
| 63 | Wed Mar 1 | atPistons | W117-115 | 29-34 | .460 | Little Caesars Arena · Detroit, MI |
| 64 | Fri Mar 3 | vsSuns | L104-125 | 29-35 | .453 | United Center · Chicago, IL |
| 65 | Sun Mar 5 | vsPacers | L122-125 | 29-36 | .446 | United Center · Chicago, IL |
| 66 | Wed Mar 8 | atNuggets | W117-96 | 30-36 | .455 | Ball Arena · Denver, CO |
| 67 | Sat Mar 11 | atRockets | W119-111 | 31-36 | .463 | Toyota Center · Houston, TX |
| 68 | Wed Mar 15 | vsKings | L114-117 | 31-37 | .456 | United Center · Chicago, IL |
| 69 | Fri Mar 17 | vsT-wolves | W139-131 (2OT) | 32-37 | .464 | United Center · Chicago, IL |
| 70 | Sat Mar 18 | vsHeat | W113-99 | 33-37 | .471 | United Center · Chicago, IL |
| 71 | Mon Mar 20 | at76ers | W109-105 (2OT) | 34-37 | .479 | Wells Fargo Center · Philadelphia, PA |
| 72 | Wed Mar 22 | vs76ers | L91-116 | 34-38 | .472 | United Center · Chicago, IL |
| 73 | Fri Mar 24 | atBlazers | W124-96 | 35-38 | .479 | Moda Center · Portland, OR |
| 74 | Sun Mar 26 | at Lakers | W118-108 | 36-38 | .486 | Crypto.com Arena · Los Angeles, CA |
| 75 | Mon Mar 27 | atClippers | L112-124 | 36-39 | .480 | Crypto.com Arena · Los Angeles, CA |
| 76 | Wed Mar 29 | vsLakers | L110-121 | 36-40 | .474 | United Center · Chicago, IL |
| 77 | Fri Mar 31 | atHornets | W121-91 | 37-40 | .481 | Spectrum Center · Charlotte, NC |
| 78 | Sun Apr 2 | vsGrizzlies | W128-107 | 38-40 | .487 | United Center · Chicago, IL |
| 79 | Tue Apr 4 | vsHawks | L105-123 | 38-41 | .481 | United Center · Chicago, IL |
| 80 | Wed Apr 5 | atBucks | L92-105 | 38-42 | .475 | Fiserv Forum · Milwaukee, WI |
| 81 | Fri Apr 7 | atMavericks | W115-112 | 39-42 | .481 | American Airlines Center · Dallas, TX |
| 82 | Sun Apr 9 | vsPistons | W103-81 | 40-42 | .488 | United Center · Chicago, IL |
| 0 | Wed Apr 12 | atRaptors | W109-105 | 1-0 | 1.000 | Scotiabank Arena · Toronto, ON |
| 0 | Fri Apr 14 | atHeat | L91-102 | 1-1 | .500 | FTX Arena · Miami, FL |
