| 1 | Wed Oct 20 | at Pistons | W94-88 | 1-0 | 1.000 | Little Caesars Arena · Detroit, MI |
| 2 | Fri Oct 22 | vs Pelicans | W128-112 | 2-0 | 1.000 | United Center · Chicago, IL |
| 3 | Sat Oct 23 | vsPistons | W97-82 | 3-0 | 1.000 | United Center · Chicago, IL |
| 4 | Mon Oct 25 | at Raptors | W111-108 | 4-0 | 1.000 | Scotiabank Arena · Toronto, ON |
| 5 | Thu Oct 28 | vs Knicks | L103-104 | 4-1 | .800 | United Center · Chicago, IL |
| 6 | Sat Oct 30 | vs Jazz | W107-99 | 5-1 | .833 | United Center · Chicago, IL |
| 7 | Mon Nov 1 | at Celtics | W128-114 | 6-1 | .857 | TD Garden · Boston, MA |
| 8 | Wed Nov 3 | at 76ers | L98-103 | 6-2 | .750 | Wells Fargo Center · Philadelphia, PA |
| 9 | Sat Nov 6 | vs76ers | L105-114 | 6-3 | .667 | United Center · Chicago, IL |
| 10 | Mon Nov 8 | vs Nets | W118-95 | 7-3 | .700 | United Center · Chicago, IL |
| 11 | Wed Nov 10 | vs Mavericks | W117-107 | 8-3 | .727 | United Center · Chicago, IL |
| 12 | Fri Nov 12 | at Warriors | L93-119 | 8-4 | .667 | Chase Center · San Francisco, CA |
| 13 | Sun Nov 14 | at Clippers | W100-90 | 9-4 | .692 | Crypto.com Arena · Los Angeles, CA |
| 14 | Mon Nov 15 | at Lakers | W121-103 | 10-4 | .714 | Crypto.com Arena · Los Angeles, CA |
| 15 | Wed Nov 17 | at Blazers | L107-112 | 10-5 | .667 | Moda Center · Portland, OR |
| 16 | Fri Nov 19 | at Nuggets | W114-108 | 11-5 | .688 | Ball Arena · Denver, CO |
| 17 | Sun Nov 21 | vsKnicks | W109-103 | 12-5 | .706 | United Center · Chicago, IL |
| 18 | Mon Nov 22 | vs Pacers | L77-109 | 12-6 | .667 | United Center · Chicago, IL |
| 19 | Wed Nov 24 | at Rockets | L113-118 | 12-7 | .632 | Toyota Center · Houston, TX |
| 20 | Fri Nov 26 | at Magic | W123-88 | 13-7 | .650 | Amway Center · Orlando, FL |
| 21 | Sat Nov 27 | vs Heat | L104-107 | 13-8 | .619 | United Center · Chicago, IL |
| 22 | Mon Nov 29 | vs Hornets | W133-119 | 14-8 | .636 | United Center · Chicago, IL |
| 23 | Thu Dec 2 | atKnicks | W119-115 | 15-8 | .652 | Madison Square Garden · Manhattan, NY |
| 24 | Sat Dec 4 | atNets | W111-107 | 16-8 | .667 | Barclays Center · Brooklyn, NY |
| 25 | Mon Dec 6 | vsNuggets | W109-97 | 17-8 | .680 | United Center · Chicago, IL |
| 26 | Wed Dec 8 | at Cavaliers | L92-115 | 17-9 | .654 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 27 | Sat Dec 11 | atHeat | L92-118 | 17-10 | .630 | FTX Arena · Miami, FL |
| 28 | Sun Dec 19 | vsLakers | W115-110 | 18-10 | .643 | United Center · Chicago, IL |
| 29 | Mon Dec 20 | vsRockets | W133-118 | 19-10 | .655 | United Center · Chicago, IL |
| 30 | Sun Dec 26 | vsPacers | W113-105 | 20-10 | .667 | United Center · Chicago, IL |
| 31 | Mon Dec 27 | at Hawks | W130-118 | 21-10 | .677 | State Farm Arena · Atlanta, GA |
| 32 | Wed Dec 29 | vsHawks | W131-117 | 22-10 | .688 | United Center · Chicago, IL |
| 33 | Fri Dec 31 | atPacers | W108-106 | 23-10 | .697 | Gainbridge Fieldhouse · Indianapolis, IN |
| 34 | Sat Jan 1 | at Wizards | W120-119 | 24-10 | .706 | Capital One Arena · Washington, D.C. |
| 35 | Mon Jan 3 | vsMagic | W102-98 | 25-10 | .714 | United Center · Chicago, IL |
| 36 | Fri Jan 7 | vsWizards | W130-122 | 26-10 | .722 | United Center · Chicago, IL |
| 37 | Sun Jan 9 | atMavericks | L99-113 | 26-11 | .703 | American Airlines Center · Dallas, TX |
| 38 | Tue Jan 11 | vsPistons | W133-87 | 27-11 | .711 | United Center · Chicago, IL |
| 39 | Wed Jan 12 | vsNets | L112-138 | 27-12 | .692 | United Center · Chicago, IL |
| 40 | Fri Jan 14 | vsWarriors | L96-138 | 27-13 | .675 | United Center · Chicago, IL |
| 41 | Sat Jan 15 | atCeltics | L112-114 | 27-14 | .659 | TD Garden · Boston, MA |
| 42 | Mon Jan 17 | at Grizzlies | L106-119 | 27-15 | .643 | FedExForum · Memphis, TN |
| 43 | Wed Jan 19 | vsCavaliers | W117-104 | 28-15 | .651 | United Center · Chicago, IL |
| 44 | Fri Jan 21 | at Bucks | L90-94 | 28-16 | .636 | Fiserv Forum · Milwaukee, WI |
| 45 | Sun Jan 23 | atMagic | L95-114 | 28-17 | .622 | Amway Center · Orlando, FL |
| 46 | Mon Jan 24 | at Thunder | W111-110 | 29-17 | .630 | Paycom Center · Oklahoma City, OK |
| 47 | Wed Jan 26 | vsRaptors | W111-105 | 30-17 | .638 | United Center · Chicago, IL |
| 48 | Fri Jan 28 | at Spurs | L122-131 | 30-18 | .625 | AT&T Center · San Antonio, TX |
| 49 | Sun Jan 30 | vsBlazers | W130-116 | 31-18 | .633 | United Center · Chicago, IL |
| 50 | Tue Feb 1 | vsMagic | W126-115 | 32-18 | .640 | United Center · Chicago, IL |
| 51 | Thu Feb 3 | atRaptors | L120-127 (OT) | 32-19 | .627 | Scotiabank Arena · Toronto, ON |
| 52 | Fri Feb 4 | atPacers | W122-115 | 33-19 | .635 | Gainbridge Fieldhouse · Indianapolis, IN |
| 53 | Sun Feb 6 | vs76ers | L108-119 | 33-20 | .623 | United Center · Chicago, IL |
| 54 | Mon Feb 7 | vs Suns | L124-127 | 33-21 | .611 | United Center · Chicago, IL |
| 55 | Wed Feb 9 | atHornets | W121-109 | 34-21 | .618 | Spectrum Center · Charlotte, NC |
| 56 | Fri Feb 11 | vs T-wolves | W134-122 | 35-21 | .625 | United Center · Chicago, IL |
| 57 | Sat Feb 12 | vsThunder | W106-101 | 36-21 | .632 | United Center · Chicago, IL |
| 58 | Mon Feb 14 | vsSpurs | W120-109 | 37-21 | .638 | United Center · Chicago, IL |
| 59 | Wed Feb 16 | vs Kings | W125-118 | 38-21 | .644 | United Center · Chicago, IL |
| 60 | Thu Feb 24 | vsHawks | W112-108 | 39-21 | .650 | United Center · Chicago, IL |
| 61 | Sat Feb 26 | vsGrizzlies | L110-116 | 39-22 | .639 | United Center · Chicago, IL |
| 62 | Mon Feb 28 | atHeat | L99-112 | 39-23 | .629 | FTX Arena · Miami, FL |
| 63 | Thu Mar 3 | atHawks | L124-130 | 39-24 | .619 | State Farm Arena · Atlanta, GA |
| 64 | Fri Mar 4 | vsBucks | L112-118 | 39-25 | .609 | United Center · Chicago, IL |
| 65 | Mon Mar 7 | at76ers | L106-121 | 39-26 | .600 | Wells Fargo Center · Philadelphia, PA |
| 66 | Wed Mar 9 | atPistons | W114-108 | 40-26 | .606 | Little Caesars Arena · Detroit, MI |
| 67 | Sat Mar 12 | vsCavaliers | W101-91 | 41-26 | .612 | United Center · Chicago, IL |
| 68 | Mon Mar 14 | atKings | L103-112 | 41-27 | .603 | Golden 1 Center · Sacramento, CA |
| 69 | Wed Mar 16 | atJazz | L110-125 | 41-28 | .594 | Vivint Arena · Salt Lake City, UT |
| 70 | Fri Mar 18 | atSuns | L102-129 | 41-29 | .586 | Footprint Center · Phoenix, AZ |
| 71 | Mon Mar 21 | vsRaptors | W113-99 | 42-29 | .592 | United Center · Chicago, IL |
| 72 | Tue Mar 22 | atBucks | L98-126 | 42-30 | .583 | Fiserv Forum · Milwaukee, WI |
| 73 | Thu Mar 24 | atPelicans | L109-126 | 42-31 | .575 | Smoothie King Center · New Orleans, LA |
| 74 | Sat Mar 26 | atCavaliers | W98-94 | 43-31 | .581 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 75 | Mon Mar 28 | atKnicks | L104-109 | 43-32 | .573 | Madison Square Garden · Manhattan, NY |
| 76 | Tue Mar 29 | atWizards | W107-94 | 44-32 | .579 | Capital One Arena · Washington, D.C. |
| 77 | Thu Mar 31 | vsClippers | W135-130 (OT) | 45-32 | .584 | United Center · Chicago, IL |
| 78 | Sat Apr 2 | vsHeat | L109-127 | 45-33 | .577 | United Center · Chicago, IL |
| 79 | Tue Apr 5 | vsBucks | L106-127 | 45-34 | .570 | United Center · Chicago, IL |
| 80 | Wed Apr 6 | vsCeltics | L94-117 | 45-35 | .563 | United Center · Chicago, IL |
| 81 | Fri Apr 8 | vsHornets | L117-133 | 45-36 | .556 | United Center · Chicago, IL |
| 82 | Sun Apr 10 | atT-wolves | W124-120 | 46-36 | .561 | Target Center · Minneapolis, MN |
| 1 | Sun Apr 17 | atBucks | L86-93 | 0-1 | .000 | Fiserv Forum · Milwaukee, WI |
| 2 | Wed Apr 20 | atBucks | W114-110 | 1-1 | .500 | Fiserv Forum · Milwaukee, WI |
| 3 | Fri Apr 22 | vsBucks | L81-111 | 1-2 | .333 | United Center · Chicago, IL |
| 4 | Sun Apr 24 | vsBucks | L95-119 | 1-3 | .250 | United Center · Chicago, IL |
| 5 | Wed Apr 27 | atBucks | L100-116 | 1-4 | .200 | Fiserv Forum · Milwaukee, WI |
