| 1 | Thu Oct 18 | at 76ers | L108-127 | 0-1 | .000 | Wells Fargo Center · Philadelphia, PA |
| 2 | Sat Oct 20 | vs Pistons | L116-118 | 0-2 | .000 | United Center · Chicago, IL |
| 3 | Mon Oct 22 | at Mavericks | L109-115 | 0-3 | .000 | American Airlines Center · Dallas, TX |
| 4 | Wed Oct 24 | vs Hornets | W112-110 | 1-3 | .250 | United Center · Chicago, IL |
| 5 | Fri Oct 26 | atHornets | L106-135 | 1-4 | .200 | Spectrum Center · Charlotte, NC |
| 6 | Sat Oct 27 | at Hawks | W97-85 | 2-4 | .333 | State Farm Arena · Atlanta, GA |
| 7 | Mon Oct 29 | vs Warriors | L124-149 | 2-5 | .286 | United Center · Chicago, IL |
| 8 | Wed Oct 31 | vs Nuggets | L107-108 (OT) | 2-6 | .250 | United Center · Chicago, IL |
| 9 | Fri Nov 2 | vs Pacers | L105-107 | 2-7 | .222 | United Center · Chicago, IL |
| 10 | Sat Nov 3 | vs Rockets | L88-96 | 2-8 | .200 | United Center · Chicago, IL |
| 11 | Mon Nov 5 | at Knicks | W116-115 (2OT) | 3-8 | .273 | Madison Square Garden · Manhattan, NY |
| 12 | Wed Nov 7 | at Pelicans | L98-107 | 3-9 | .250 | Smoothie King Center · New Orleans, LA |
| 13 | Sat Nov 10 | vs Cavaliers | W99-98 | 4-9 | .308 | United Center · Chicago, IL |
| 14 | Mon Nov 12 | vsMavericks | L98-103 | 4-10 | .286 | United Center · Chicago, IL |
| 15 | Wed Nov 14 | at Celtics | L82-111 | 4-11 | .267 | TD Garden · Boston, MA |
| 16 | Fri Nov 16 | at Bucks | L104-123 | 4-12 | .250 | Fiserv Forum · Milwaukee, WI |
| 17 | Sat Nov 17 | vs Raptors | L83-122 | 4-13 | .235 | United Center · Chicago, IL |
| 18 | Wed Nov 21 | vs Suns | W124-116 | 5-13 | .278 | United Center · Chicago, IL |
| 19 | Fri Nov 23 | vs Heat | L96-103 | 5-14 | .263 | United Center · Chicago, IL |
| 20 | Sat Nov 24 | at T-wolves | L96-111 | 5-15 | .250 | Target Center · Minneapolis, MN |
| 21 | Mon Nov 26 | vs Spurs | L107-108 | 5-16 | .238 | United Center · Chicago, IL |
| 22 | Wed Nov 28 | atBucks | L113-116 | 5-17 | .227 | Fiserv Forum · Milwaukee, WI |
| 23 | Fri Nov 30 | atPistons | L88-107 | 5-18 | .217 | Little Caesars Arena · Detroit, MI |
| 24 | Sat Dec 1 | atRockets | L105-121 | 5-19 | .208 | Toyota Center · Houston, TX |
| 25 | Tue Dec 4 | atPacers | L90-96 | 5-20 | .200 | Gainbridge Fieldhouse · Indianapolis, IN |
| 26 | Fri Dec 7 | vs Thunder | W114-112 | 6-20 | .231 | United Center · Chicago, IL |
| 27 | Sat Dec 8 | vsCeltics | L77-133 | 6-21 | .222 | United Center · Chicago, IL |
| 28 | Mon Dec 10 | vs Kings | L89-108 | 6-22 | .214 | United Center · Chicago, IL |
| 29 | Thu Dec 13 | at Magic | L91-97 | 6-23 | .207 | Amway Center · Orlando, FL |
| 30 | Sat Dec 15 | atSpurs | W98-93 | 7-23 | .233 | AT&T Center · San Antonio, TX |
| 31 | Mon Dec 17 | atThunder | L96-121 | 7-24 | .226 | Paycom Center · Oklahoma City, OK |
| 32 | Wed Dec 19 | vs Nets | L93-96 | 7-25 | .219 | United Center · Chicago, IL |
| 33 | Fri Dec 21 | vsMagic | W90-80 | 8-25 | .242 | United Center · Chicago, IL |
| 34 | Sun Dec 23 | atCavaliers | W112-92 | 9-25 | .265 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 35 | Wed Dec 26 | vsT-wolves | L94-119 | 9-26 | .257 | United Center · Chicago, IL |
| 36 | Fri Dec 28 | at Wizards | W101-92 | 10-26 | .278 | Capital One Arena · Washington, D.C. |
| 37 | Sun Dec 30 | atRaptors | L89-95 | 10-27 | .270 | Scotiabank Arena · Toronto, ON |
| 38 | Wed Jan 2 | vsMagic | L84-112 | 10-28 | .263 | United Center · Chicago, IL |
| 39 | Fri Jan 4 | vsPacers | L116-119 (OT) | 10-29 | .256 | United Center · Chicago, IL |
| 40 | Sun Jan 6 | vsNets | L100-117 | 10-30 | .250 | United Center · Chicago, IL |
| 41 | Wed Jan 9 | at Blazers | L112-124 | 10-31 | .244 | Moda Center · Portland, OR |
| 42 | Fri Jan 11 | atWarriors | L109-146 | 10-32 | .238 | Chase Center · San Francisco, CA |
| 43 | Sat Jan 12 | at Jazz | L102-110 | 10-33 | .233 | Vivint Arena · Salt Lake City, UT |
| 44 | Tue Jan 15 | at Lakers | L100-107 | 10-34 | .227 | Crypto.com Arena · Los Angeles, CA |
| 45 | Thu Jan 17 | atNuggets | L105-135 | 10-35 | .222 | Ball Arena · Denver, CO |
| 46 | Sat Jan 19 | vsHeat | L103-117 | 10-36 | .217 | United Center · Chicago, IL |
| 47 | Mon Jan 21 | atCavaliers | W104-88 | 11-36 | .234 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 48 | Wed Jan 23 | vsHawks | L101-121 | 11-37 | .229 | United Center · Chicago, IL |
| 49 | Fri Jan 25 | vs Clippers | L101-106 | 11-38 | .224 | United Center · Chicago, IL |
| 50 | Sun Jan 27 | vsCavaliers | L101-104 | 11-39 | .220 | United Center · Chicago, IL |
| 51 | Tue Jan 29 | atNets | L117-122 | 11-40 | .216 | Barclays Center · Brooklyn, NY |
| 52 | Wed Jan 30 | atHeat | W105-89 | 12-40 | .231 | FTX Arena · Miami, FL |
| 53 | Sat Feb 2 | atHornets | L118-125 | 12-41 | .226 | Spectrum Center · Charlotte, NC |
| 54 | Wed Feb 6 | vsPelicans | L120-125 | 12-42 | .222 | United Center · Chicago, IL |
| 55 | Fri Feb 8 | atNets | W125-106 | 13-42 | .236 | Barclays Center · Brooklyn, NY |
| 56 | Sat Feb 9 | vsWizards | L125-134 | 13-43 | .232 | United Center · Chicago, IL |
| 57 | Mon Feb 11 | vsBucks | L99-112 | 13-44 | .228 | United Center · Chicago, IL |
| 58 | Wed Feb 13 | vs Grizzlies | W122-110 | 14-44 | .241 | United Center · Chicago, IL |
| 59 | Fri Feb 22 | atMagic | W110-109 | 15-44 | .254 | Amway Center · Orlando, FL |
| 60 | Sat Feb 23 | vsCeltics | W126-116 | 16-44 | .267 | United Center · Chicago, IL |
| 61 | Mon Feb 25 | vsBucks | L106-117 | 16-45 | .262 | United Center · Chicago, IL |
| 62 | Wed Feb 27 | atGrizzlies | W109-107 | 17-45 | .274 | FedExForum · Memphis, TN |
| 63 | Fri Mar 1 | atHawks | W168-161 (OT) | 18-45 | .286 | State Farm Arena · Atlanta, GA |
| 64 | Sun Mar 3 | vsHawks | L118-123 | 18-46 | .281 | United Center · Chicago, IL |
| 65 | Tue Mar 5 | atPacers | L96-105 | 18-47 | .277 | Gainbridge Fieldhouse · Indianapolis, IN |
| 66 | Wed Mar 6 | vs76ers | W108-107 | 19-47 | .288 | United Center · Chicago, IL |
| 67 | Fri Mar 8 | vsPistons | L104-112 | 19-48 | .284 | United Center · Chicago, IL |
| 68 | Sun Mar 10 | atPistons | L108-131 | 19-49 | .279 | Little Caesars Arena · Detroit, MI |
| 69 | Tue Mar 12 | vsLakers | L107-123 | 19-50 | .275 | United Center · Chicago, IL |
| 70 | Fri Mar 15 | atClippers | L121-128 | 19-51 | .271 | Crypto.com Arena · Los Angeles, CA |
| 71 | Sun Mar 17 | atKings | L102-129 | 19-52 | .268 | Golden 1 Center · Sacramento, CA |
| 72 | Mon Mar 18 | atSuns | W116-101 | 20-52 | .278 | Footprint Center · Phoenix, AZ |
| 73 | Wed Mar 20 | vsWizards | W126-120 (OT) | 21-52 | .288 | United Center · Chicago, IL |
| 74 | Sat Mar 23 | vsJazz | L83-114 | 21-53 | .284 | United Center · Chicago, IL |
| 75 | Tue Mar 26 | atRaptors | L103-112 | 21-54 | .280 | Scotiabank Arena · Toronto, ON |
| 76 | Wed Mar 27 | vsBlazers | L98-118 | 21-55 | .276 | United Center · Chicago, IL |
| 77 | Sat Mar 30 | vsRaptors | L101-124 | 21-56 | .273 | United Center · Chicago, IL |
| 78 | Mon Apr 1 | atKnicks | L105-113 | 21-57 | .269 | Madison Square Garden · Manhattan, NY |
| 79 | Wed Apr 3 | atWizards | W115-114 | 22-57 | .278 | Capital One Arena · Washington, D.C. |
| 80 | Sat Apr 6 | vs76ers | L96-116 | 22-58 | .275 | United Center · Chicago, IL |
| 81 | Tue Apr 9 | vsKnicks | L86-96 | 22-59 | .272 | United Center · Chicago, IL |
| 82 | Wed Apr 10 | at76ers | L109-125 | 22-60 | .268 | Wells Fargo Center · Philadelphia, PA |
