| 1 | Wed Oct 25 | vs Thunder | L104-124 | 0-1 | .000 | United Center · Chicago, IL |
| 2 | Fri Oct 27 | vs Raptors | W104-103 (OT) | 1-1 | .500 | United Center · Chicago, IL |
| 3 | Sat Oct 28 | at Pistons | L102-118 | 1-2 | .333 | Little Caesars Arena · Detroit, MI |
| 4 | Mon Oct 30 | at Pacers | W112-105 | 2-2 | .500 | Gainbridge Fieldhouse · Indianapolis, IN |
| 5 | Wed Nov 1 | at Mavericks | L105-114 | 2-3 | .400 | American Airlines Center · Dallas, TX |
| 6 | Fri Nov 3 | vs Nets | L107-109 | 2-4 | .333 | United Center · Chicago, IL |
| 7 | Sat Nov 4 | at Nuggets | L101-123 | 2-5 | .286 | Ball Arena · Denver, CO |
| 8 | Mon Nov 6 | vs Jazz | W130-113 | 3-5 | .375 | United Center · Chicago, IL |
| 9 | Wed Nov 8 | vs Suns | L115-116 (OT) | 3-6 | .333 | United Center · Chicago, IL |
| 10 | Sun Nov 12 | vsPistons | W119-108 | 4-6 | .400 | United Center · Chicago, IL |
| 11 | Mon Nov 13 | at Bucks | L109-118 | 4-7 | .364 | Fiserv Forum · Milwaukee, WI |
| 12 | Wed Nov 15 | vs Magic | L94-96 | 4-8 | .333 | United Center · Chicago, IL |
| 13 | Fri Nov 17 | vsMagic | L97-103 | 4-9 | .308 | United Center · Chicago, IL |
| 14 | Sat Nov 18 | vs Heat | W102-97 | 5-9 | .357 | United Center · Chicago, IL |
| 15 | Mon Nov 20 | vsHeat | L100-118 | 5-10 | .333 | United Center · Chicago, IL |
| 16 | Wed Nov 22 | atThunder | L102-116 | 5-11 | .313 | Paycom Center · Oklahoma City, OK |
| 17 | Fri Nov 24 | atRaptors | L108-121 | 5-12 | .294 | Scotiabank Arena · Toronto, ON |
| 18 | Sun Nov 26 | atNets | L109-118 | 5-13 | .278 | Barclays Center · Brooklyn, NY |
| 19 | Tue Nov 28 | at Celtics | L97-124 | 5-14 | .263 | TD Garden · Boston, MA |
| 20 | Thu Nov 30 | vsBucks | W120-113 (OT) | 6-14 | .300 | United Center · Chicago, IL |
| 21 | Sat Dec 2 | vs Pelicans | W124-118 | 7-14 | .333 | United Center · Chicago, IL |
| 22 | Wed Dec 6 | vs Hornets | W111-100 | 8-14 | .364 | United Center · Chicago, IL |
| 23 | Fri Dec 8 | at Spurs | W121-112 | 9-14 | .391 | AT&T Center · San Antonio, TX |
| 24 | Mon Dec 11 | atBucks | L129-133 (OT) | 9-15 | .375 | Fiserv Forum · Milwaukee, WI |
| 25 | Tue Dec 12 | vsNuggets | L106-114 | 9-16 | .360 | United Center · Chicago, IL |
| 26 | Thu Dec 14 | atHeat | W124-116 | 10-16 | .385 | FTX Arena · Miami, FL |
| 27 | Sat Dec 16 | atHeat | L116-118 | 10-17 | .370 | FTX Arena · Miami, FL |
| 28 | Mon Dec 18 | at 76ers | W108-104 | 11-17 | .393 | Wells Fargo Center · Philadelphia, PA |
| 29 | Wed Dec 20 | vs Lakers | W124-108 | 12-17 | .414 | United Center · Chicago, IL |
| 30 | Thu Dec 21 | vsSpurs | W114-95 | 13-17 | .433 | United Center · Chicago, IL |
| 31 | Sat Dec 23 | vs Cavaliers | L95-109 | 13-18 | .419 | United Center · Chicago, IL |
| 32 | Tue Dec 26 | vs Hawks | W118-113 | 14-18 | .438 | United Center · Chicago, IL |
| 33 | Thu Dec 28 | vsPacers | L104-120 | 14-19 | .424 | United Center · Chicago, IL |
| 34 | Sat Dec 30 | vs76ers | W105-92 | 15-19 | .441 | United Center · Chicago, IL |
| 35 | Tue Jan 2 | at76ers | L97-110 | 15-20 | .429 | Wells Fargo Center · Philadelphia, PA |
| 36 | Wed Jan 3 | at Knicks | L100-116 | 15-21 | .417 | Madison Square Garden · Manhattan, NY |
| 37 | Fri Jan 5 | vsHornets | W104-91 | 16-21 | .432 | United Center · Chicago, IL |
| 38 | Mon Jan 8 | atHornets | W119-112 (OT) | 17-21 | .447 | Spectrum Center · Charlotte, NC |
| 39 | Wed Jan 10 | vs Rockets | W124-119 (OT) | 18-21 | .462 | United Center · Chicago, IL |
| 40 | Fri Jan 12 | vs Warriors | L131-140 | 18-22 | .450 | United Center · Chicago, IL |
| 41 | Sat Jan 13 | atSpurs | W122-116 | 19-22 | .463 | AT&T Center · San Antonio, TX |
| 42 | Mon Jan 15 | atCavaliers | L91-109 | 19-23 | .452 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 43 | Thu Jan 18 | atRaptors | W116-110 | 20-23 | .465 | Scotiabank Arena · Toronto, ON |
| 44 | Sat Jan 20 | vs Grizzlies | W125-96 | 21-23 | .477 | United Center · Chicago, IL |
| 45 | Mon Jan 22 | atSuns | L113-115 | 21-24 | .467 | Footprint Center · Phoenix, AZ |
| 46 | Thu Jan 25 | atLakers | L132-141 | 21-25 | .457 | Crypto.com Arena · Los Angeles, CA |
| 47 | Sun Jan 28 | at Blazers | W104-96 | 22-25 | .468 | Moda Center · Portland, OR |
| 48 | Tue Jan 30 | vsRaptors | L107-118 | 22-26 | .458 | United Center · Chicago, IL |
| 49 | Wed Jan 31 | atHornets | W117-110 | 23-26 | .469 | Spectrum Center · Charlotte, NC |
| 50 | Sat Feb 3 | vs Kings | L115-123 | 23-27 | .460 | United Center · Chicago, IL |
| 51 | Tue Feb 6 | vs T-wolves | W129-123 (OT) | 24-27 | .471 | United Center · Chicago, IL |
| 52 | Thu Feb 8 | atGrizzlies | W118-110 | 25-27 | .481 | FedExForum · Memphis, TN |
| 53 | Sat Feb 10 | atMagic | L108-114 (OT) | 25-28 | .472 | Amway Center · Orlando, FL |
| 54 | Mon Feb 12 | atHawks | W136-126 | 26-28 | .481 | State Farm Arena · Atlanta, GA |
| 55 | Wed Feb 14 | atCavaliers | L105-108 | 26-29 | .473 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 56 | Thu Feb 22 | vsCeltics | L112-129 | 26-30 | .464 | United Center · Chicago, IL |
| 57 | Sun Feb 25 | atPelicans | W114-106 | 27-30 | .474 | Smoothie King Center · New Orleans, LA |
| 58 | Tue Feb 27 | vsPistons | L95-105 | 27-31 | .466 | United Center · Chicago, IL |
| 59 | Wed Feb 28 | vsCavaliers | W132-123 (2OT) | 28-31 | .475 | United Center · Chicago, IL |
| 60 | Fri Mar 1 | vsBucks | L97-113 | 28-32 | .467 | United Center · Chicago, IL |
| 61 | Mon Mar 4 | atKings | W113-109 | 29-32 | .475 | Golden 1 Center · Sacramento, CA |
| 62 | Wed Mar 6 | atJazz | W119-117 | 30-32 | .484 | Vivint Arena · Salt Lake City, UT |
| 63 | Thu Mar 7 | atWarriors | W125-122 | 31-32 | .492 | Chase Center · San Francisco, CA |
| 64 | Sat Mar 9 | at Clippers | L102-112 | 31-33 | .484 | Crypto.com Arena · Los Angeles, CA |
| 65 | Mon Mar 11 | vsMavericks | L92-127 | 31-34 | .477 | United Center · Chicago, IL |
| 66 | Wed Mar 13 | atPacers | W132-129 (OT) | 32-34 | .485 | Gainbridge Fieldhouse · Indianapolis, IN |
| 67 | Thu Mar 14 | vsClippers | L111-126 | 32-35 | .478 | United Center · Chicago, IL |
| 68 | Sat Mar 16 | vs Wizards | W127-98 | 33-35 | .485 | United Center · Chicago, IL |
| 69 | Mon Mar 18 | vsBlazers | W110-107 | 34-35 | .493 | United Center · Chicago, IL |
| 70 | Thu Mar 21 | atRockets | L117-127 | 34-36 | .486 | Toyota Center · Houston, TX |
| 71 | Sat Mar 23 | vsCeltics | L113-124 | 34-37 | .479 | United Center · Chicago, IL |
| 72 | Mon Mar 25 | vsWizards | L105-107 | 34-38 | .472 | United Center · Chicago, IL |
| 73 | Wed Mar 27 | vsPacers | W125-99 | 35-38 | .479 | United Center · Chicago, IL |
| 74 | Fri Mar 29 | atNets | L108-125 | 35-39 | .473 | Barclays Center · Brooklyn, NY |
| 75 | Sun Mar 31 | atT-wolves | W109-101 | 36-39 | .480 | Target Center · Minneapolis, MN |
| 76 | Mon Apr 1 | vsHawks | L101-113 | 36-40 | .474 | United Center · Chicago, IL |
| 77 | Fri Apr 5 | vsKnicks | W108-100 | 37-40 | .481 | United Center · Chicago, IL |
| 78 | Sun Apr 7 | atMagic | L98-113 | 37-41 | .474 | Amway Center · Orlando, FL |
| 79 | Tue Apr 9 | vsKnicks | L117-128 | 37-42 | .468 | United Center · Chicago, IL |
| 80 | Thu Apr 11 | atPistons | W127-105 | 38-42 | .475 | Little Caesars Arena · Detroit, MI |
| 81 | Fri Apr 12 | atWizards | W129-127 | 39-42 | .481 | Capital One Arena · Washington, D.C. |
| 82 | Sun Apr 14 | atKnicks | L119-120 (OT) | 39-43 | .476 | Madison Square Garden · Manhattan, NY |
| 0 | Wed Apr 17 | vsHawks | W131-116 | 1-0 | 1.000 | United Center · Chicago, IL |
| 0 | Fri Apr 19 | atHeat | L91-112 | 1-1 | .500 | FTX Arena · Miami, FL |
