| 1 | Wed Oct 26 | vs Mavericks | W130-121 (OT) | 1-0 | 1.000 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 2 | Fri Oct 28 | at Nets | L94-103 | 1-1 | .500 | | Barclays Center · Brooklyn, NY |
| 3 | Sat Oct 29 | at Bulls | L101-118 | 1-2 | .333 | | United Center · Chicago, IL |
| 4 | Tue Nov 1 | vs Lakers | W115-108 | 2-2 | .500 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 5 | Thu Nov 3 | at Bucks | L107-125 | 2-3 | .400 | | Fiserv Forum · Milwaukee, WI |
| 6 | Sat Nov 5 | vs Bulls | W111-94 | 3-3 | .500 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 7 | Mon Nov 7 | at Hornets | L100-122 | 3-4 | .429 | | Spectrum Center · Charlotte, NC |
| 8 | Wed Nov 9 | vs 76ers | W122-115 (OT) | 4-4 | .500 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 9 | Fri Nov 11 | at 76ers | L105-109 (OT) | 4-5 | .444 | | Wells Fargo Center · Philadelphia, PA |
| 10 | Sat Nov 12 | vs Celtics | L99-105 | 4-6 | .400 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 11 | Mon Nov 14 | vs Magic | W88-69 | 5-6 | .455 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 12 | Wed Nov 16 | vs Cavaliers | W103-93 | 6-6 | .500 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 13 | Fri Nov 18 | vs Suns | L96-116 | 6-7 | .462 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 14 | Sun Nov 20 | at Thunder | W115-111 (OT) | 7-7 | .500 | | Paycom Center · Oklahoma City, OK |
| 15 | Mon Nov 21 | vs Warriors | L83-120 | 7-8 | .467 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 16 | Wed Nov 23 | vs Hawks | L85-96 | 7-9 | .438 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 17 | Fri Nov 25 | vs Nets | W118-97 | 8-9 | .471 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 18 | Sun Nov 27 | vs Clippers | W91-70 | 9-9 | .500 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 19 | Wed Nov 30 | at Blazers | L109-131 | 9-10 | .474 | NBA TV | Moda Center · Portland, OR |
| 20 | Sun Dec 4 | at Clippers | W111-102 | 10-10 | .500 | | Intuit Dome · Inglewood, CA |
| 21 | Mon Dec 5 | at Warriors | L106-142 | 10-11 | .476 | NBA TV | Chase Center · San Francisco, CA |
| 22 | Wed Dec 7 | at Suns | W109-94 | 11-11 | .500 | | Footprint Center · Phoenix, AZ |
| 23 | Fri Dec 9 | at Mavericks | L103-111 | 11-12 | .478 | | American Airlines Center · Dallas, TX |
| 24 | Sat Dec 10 | vs Blazers | W118-111 | 12-12 | .500 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 25 | Mon Dec 12 | vs Hornets | W110-94 | 13-12 | .520 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 26 | Wed Dec 14 | at Heat | L89-95 | 13-13 | .500 | ESPN | Kaseya Center · Miami, FL |
| 27 | Thu Dec 15 | at Pelicans | L95-102 | 13-14 | .481 | | Smoothie King Center · New Orleans, LA |
| 28 | Sat Dec 17 | at Pistons | W105-90 | 14-14 | .500 | | Little Caesars Arena · Detroit, MI |
| 29 | Mon Dec 19 | vs Wizards | W107-105 | 15-14 | .517 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 30 | Tue Dec 20 | at Knicks | L111-118 | 15-15 | .500 | | Madison Square Garden · Manhattan, NY |
| 31 | Thu Dec 22 | vs Celtics | L102-109 | 15-16 | .484 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 32 | Mon Dec 26 | at Bulls | L85-90 | 15-17 | .469 | NBA TV | United Center · Chicago, IL |
| 33 | Wed Dec 28 | at Wizards | L105-111 | 15-18 | .455 | | Capital One Arena · Washington, D.C. |
| 34 | Fri Dec 30 | vs Bulls | W111-101 | 16-18 | .471 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 35 | Sun Jan 1 | vs Magic | W117-104 | 17-18 | .486 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 36 | Tue Jan 3 | at Pistons | W121-116 | 18-18 | .500 | | Little Caesars Arena · Detroit, MI |
| 37 | Thu Jan 5 | vs Nets | W121-109 | 19-18 | .514 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 38 | Sat Jan 7 | vs Knicks | W123-109 | 20-18 | .526 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 39 | Thu Jan 12 | at Nuggets | L112-140 | 20-19 | .513 | NBA TV | Ball Arena · Denver, CO |
| 40 | Mon Jan 16 | vs Pelicans | W98-95 | 21-19 | .525 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 41 | Wed Jan 18 | at Kings | W106-100 | 22-19 | .537 | | Golden 1 Center · Sacramento, CA |
| 42 | Fri Jan 20 | at Lakers | L95-108 | 22-20 | .524 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 43 | Sat Jan 21 | at Jazz | L100-109 | 22-21 | .512 | | Vivint Arena · Salt Lake City, UT |
| 44 | Mon Jan 23 | vs Knicks | L103-109 | 22-22 | .500 | TNT | Gainbridge Fieldhouse · Indianapolis, IN |
| 45 | Thu Jan 26 | at T-wolves | W109-103 | 23-22 | .511 | | Target Center · Minneapolis, MN |
| 46 | Fri Jan 27 | vs Kings | W115-111 (OT) | 24-22 | .522 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 47 | Sun Jan 29 | vs Rockets | W120-101 | 25-22 | .532 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 48 | Wed Feb 1 | at Magic | W98-88 | 26-22 | .542 | | Amway Center · Orlando, FL |
| 49 | Fri Feb 3 | at Nets | W106-97 | 27-22 | .551 | | Barclays Center · Brooklyn, NY |
| 50 | Sat Feb 4 | vs Pistons | W105-84 | 28-22 | .560 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 51 | Mon Feb 6 | vs Thunder | W93-90 | 29-22 | .569 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 52 | Wed Feb 8 | vs Cavaliers | L117-132 | 29-23 | .558 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 53 | Fri Feb 10 | at Wizards | L107-112 | 29-24 | .547 | ESPN | Capital One Arena · Washington, D.C. |
| 54 | Sat Feb 11 | vs Bucks | L100-116 | 29-25 | .537 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 55 | Mon Feb 13 | vs Spurs | L106-110 | 29-26 | .527 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 56 | Wed Feb 15 | at Cavaliers | L104-113 | 29-27 | .518 | ESPN | Rocket Mortgage FieldHouse · Cleveland, OH |
| 57 | Thu Feb 16 | vs Wizards | L98-111 | 29-28 | .509 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 58 | Fri Feb 24 | vs Grizzlies | W102-92 | 30-28 | .517 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 59 | Sat Feb 25 | at Heat | L95-113 | 30-29 | .508 | | Kaseya Center · Miami, FL |
| 60 | Mon Feb 27 | at Rockets | W117-108 | 31-29 | .517 | TNT | Toyota Center · Houston, TX |
| 61 | Wed Mar 1 | at Spurs | L99-100 | 31-30 | .508 | | AT&T Center · San Antonio, TX |
| 62 | Sun Mar 5 | at Hawks | W97-96 | 32-30 | .516 | | State Farm Arena · Atlanta, GA |
| 63 | Mon Mar 6 | at Hornets | L88-100 | 32-31 | .508 | TNT | Spectrum Center · Charlotte, NC |
| 64 | Wed Mar 8 | vs Pistons | W115-98 | 33-31 | .516 | ESPN | Gainbridge Fieldhouse · Indianapolis, IN |
| 65 | Fri Mar 10 | at Bucks | L85-99 | 33-32 | .508 | | Fiserv Forum · Milwaukee, WI |
| 66 | Sun Mar 12 | vs Heat | W102-98 | 34-32 | .515 | NBA TV | Gainbridge Fieldhouse · Indianapolis, IN |
| 67 | Tue Mar 14 | at Knicks | L81-87 | 34-33 | .507 | | Madison Square Garden · Manhattan, NY |
| 68 | Wed Mar 15 | vs Hornets | W98-77 | 35-33 | .515 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 69 | Sun Mar 19 | at Raptors | L91-116 | 35-34 | .507 | NBA TV | Scotiabank Arena · Toronto, ON |
| 70 | Mon Mar 20 | vs Jazz | W107-100 | 36-34 | .514 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 71 | Wed Mar 22 | at Celtics | L100-109 | 36-35 | .507 | | TD Garden · Boston, MA |
| 72 | Fri Mar 24 | vs Nuggets | L117-125 | 36-36 | .500 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 73 | Sun Mar 26 | vs 76ers | W107-94 | 37-36 | .507 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 74 | Tue Mar 28 | vs T-wolves | L114-115 | 37-37 | .500 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 75 | Wed Mar 29 | at Grizzlies | L97-110 | 37-38 | .493 | | FedExForum · Memphis, TN |
| 76 | Fri Mar 31 | at Raptors | L100-111 | 37-39 | .487 | | Scotiabank Arena · Toronto, ON |
| 77 | Sun Apr 2 | at Cavaliers | L130-135 (2OT) | 37-40 | .481 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 78 | Tue Apr 4 | vs Raptors | W108-90 | 38-40 | .487 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 79 | Thu Apr 6 | vs Bucks | W104-89 | 39-40 | .494 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 80 | Sat Apr 8 | at Magic | W127-112 | 40-40 | .500 | | Amway Center · Orlando, FL |
| 81 | Mon Apr 10 | at 76ers | W120-111 | 41-40 | .506 | | Wells Fargo Center · Philadelphia, PA |
| 82 | Wed Apr 12 | vs Hawks | W104-86 | 42-40 | .512 | ESPN | Gainbridge Fieldhouse · Indianapolis, IN |
| 1 | Sat Apr 15 | at Cavaliers | L108-109 | 0-1 | .000 | ABC | Rocket Mortgage FieldHouse · Cleveland, OH |
| 2 | Mon Apr 17 | at Cavaliers | L111-117 | 0-2 | .000 | TNT | Rocket Mortgage FieldHouse · Cleveland, OH |
| 3 | Thu Apr 20 | vs Cavaliers | L114-119 | 0-3 | .000 | TNT | Gainbridge Fieldhouse · Indianapolis, IN |
| 4 | Sun Apr 23 | vs Cavaliers | L102-106 | 0-4 | .000 | ABC | Gainbridge Fieldhouse · Indianapolis, IN |