| 1 | Wed Oct 17 | vs Grizzlies | W111-83 | 1-0 | 1.000 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 2 | Fri Oct 19 | at Bucks | L101-118 | 1-1 | .500 | | Fiserv Forum · Milwaukee, WI |
| 3 | Sat Oct 20 | vs Nets | W132-112 | 2-1 | .667 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 4 | Mon Oct 22 | at T-wolves | L91-101 | 2-2 | .500 | | Target Center · Minneapolis, MN |
| 5 | Wed Oct 24 | at Spurs | W116-96 | 3-2 | .600 | | AT&T Center · San Antonio, TX |
| 6 | Sat Oct 27 | at Cavaliers | W119-107 | 4-2 | .667 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 7 | Mon Oct 29 | vs Blazers | L93-103 | 4-3 | .571 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 8 | Wed Oct 31 | at Knicks | W107-101 | 5-3 | .625 | ESPN | Madison Square Garden · Manhattan, NY |
| 9 | Fri Nov 2 | at Bulls | W107-105 | 6-3 | .667 | | United Center · Chicago, IL |
| 10 | Sat Nov 3 | vs Celtics | W102-101 | 7-3 | .700 | NBA TV | Gainbridge Fieldhouse · Indianapolis, IN |
| 11 | Mon Nov 5 | vs Rockets | L94-98 | 7-4 | .636 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 12 | Wed Nov 7 | vs 76ers | L94-100 | 7-5 | .583 | ESPN | Gainbridge Fieldhouse · Indianapolis, IN |
| 13 | Fri Nov 9 | at Heat | W110-102 | 8-5 | .615 | | Kaseya Center · Miami, FL |
| 14 | Sun Nov 11 | at Rockets | L103-115 | 8-6 | .571 | | Toyota Center · Houston, TX |
| 15 | Fri Nov 16 | vs Heat | W99-91 | 9-6 | .600 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 16 | Sat Nov 17 | vs Hawks | W97-89 | 10-6 | .625 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 17 | Mon Nov 19 | vs Jazz | W121-94 | 11-6 | .647 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 18 | Wed Nov 21 | at Hornets | L109-127 | 11-7 | .611 | | Spectrum Center · Charlotte, NC |
| 19 | Fri Nov 23 | vs Spurs | L100-111 | 11-8 | .579 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 20 | Mon Nov 26 | at Jazz | W121-88 | 12-8 | .600 | | Vivint Arena · Salt Lake City, UT |
| 21 | Tue Nov 27 | at Suns | W109-104 | 13-8 | .619 | | Footprint Center · Phoenix, AZ |
| 22 | Thu Nov 29 | at Lakers | L96-104 | 13-9 | .591 | | Crypto.com Arena · Los Angeles, CA |
| 23 | Sat Dec 1 | at Kings | L110-111 | 13-10 | .565 | | Golden 1 Center · Sacramento, CA |
| 24 | Tue Dec 4 | vs Bulls | W96-90 | 14-10 | .583 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 25 | Fri Dec 7 | at Magic | W112-90 | 15-10 | .600 | | Amway Center · Orlando, FL |
| 26 | Sat Dec 8 | vs Kings | W107-97 | 16-10 | .615 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 27 | Mon Dec 10 | vs Wizards | W109-101 | 17-10 | .630 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 28 | Wed Dec 12 | vs Bucks | W113-97 | 18-10 | .643 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 29 | Fri Dec 14 | at 76ers | W113-101 | 19-10 | .655 | ESPN | Wells Fargo Center · Philadelphia, PA |
| 30 | Sun Dec 16 | vs Knicks | W110-99 | 20-10 | .667 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 31 | Tue Dec 18 | vs Cavaliers | L91-92 | 20-11 | .645 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 32 | Wed Dec 19 | at Raptors | L96-99 | 20-12 | .625 | | Scotiabank Arena · Toronto, ON |
| 33 | Fri Dec 21 | at Nets | W114-106 | 21-12 | .636 | | Barclays Center · Brooklyn, NY |
| 34 | Sun Dec 23 | vs Wizards | W105-89 | 22-12 | .647 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 35 | Wed Dec 26 | at Hawks | W129-121 | 23-12 | .657 | | State Farm Arena · Atlanta, GA |
| 36 | Fri Dec 28 | vs Pistons | W125-88 | 24-12 | .667 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 37 | Mon Dec 31 | vs Hawks | W116-108 | 25-12 | .676 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 38 | Fri Jan 4 | at Bulls | W119-116 (OT) | 26-12 | .684 | | United Center · Chicago, IL |
| 39 | Sun Jan 6 | at Raptors | L105-121 | 26-13 | .667 | NBA TV | Scotiabank Arena · Toronto, ON |
| 40 | Tue Jan 8 | at Cavaliers | W123-115 | 27-13 | .675 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 41 | Wed Jan 9 | at Celtics | L108-135 | 27-14 | .659 | | TD Garden · Boston, MA |
| 42 | Fri Jan 11 | at Knicks | W121-106 | 28-14 | .667 | ESPN | Madison Square Garden · Manhattan, NY |
| 43 | Tue Jan 15 | vs Suns | W131-97 | 29-14 | .674 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 44 | Thu Jan 17 | vs 76ers | L96-120 | 29-15 | .659 | TNT | Gainbridge Fieldhouse · Indianapolis, IN |
| 45 | Sat Jan 19 | vs Mavericks | W111-99 | 30-15 | .667 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 46 | Sun Jan 20 | vs Hornets | W120-95 | 31-15 | .674 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 47 | Wed Jan 23 | vs Raptors | W110-106 | 32-15 | .681 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 48 | Sat Jan 26 | at Grizzlies | L103-106 | 32-16 | .667 | | FedExForum · Memphis, TN |
| 49 | Mon Jan 28 | vs Warriors | L100-132 | 32-17 | .653 | NBA TV | Gainbridge Fieldhouse · Indianapolis, IN |
| 50 | Wed Jan 30 | at Wizards | L89-107 | 32-18 | .640 | ESPN | Capital One Arena · Washington, D.C. |
| 51 | Thu Jan 31 | at Magic | L100-107 | 32-19 | .627 | | Amway Center · Orlando, FL |
| 52 | Sat Feb 2 | at Heat | W95-88 | 33-19 | .635 | | Kaseya Center · Miami, FL |
| 53 | Mon Feb 4 | at Pelicans | W109-107 | 34-19 | .642 | | Smoothie King Center · New Orleans, LA |
| 54 | Tue Feb 5 | vs Lakers | W136-94 | 35-19 | .648 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 55 | Thu Feb 7 | vs Clippers | W116-92 | 36-19 | .655 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 56 | Sat Feb 9 | vs Cavaliers | W105-90 | 37-19 | .661 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 57 | Mon Feb 11 | vs Hornets | W99-90 | 38-19 | .667 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 58 | Wed Feb 13 | vs Bucks | L97-106 | 38-20 | .655 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 59 | Fri Feb 22 | vs Pelicans | W126-111 | 39-20 | .661 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 60 | Sat Feb 23 | at Wizards | W119-112 | 40-20 | .667 | | Capital One Arena · Washington, D.C. |
| 61 | Mon Feb 25 | at Pistons | L109-113 | 40-21 | .656 | | Little Caesars Arena · Detroit, MI |
| 62 | Wed Feb 27 | at Mavericks | L101-110 | 40-22 | .645 | | American Airlines Center · Dallas, TX |
| 63 | Thu Feb 28 | vs T-wolves | W122-115 | 41-22 | .651 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 64 | Sat Mar 2 | vs Magic | L112-117 | 41-23 | .641 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 65 | Tue Mar 5 | vs Bulls | W105-96 | 42-23 | .646 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 66 | Thu Mar 7 | at Bucks | L98-117 | 42-24 | .636 | TNT | Fiserv Forum · Milwaukee, WI |
| 67 | Sun Mar 10 | at 76ers | L89-106 | 42-25 | .627 | ABC | Wells Fargo Center · Philadelphia, PA |
| 68 | Tue Mar 12 | vs Knicks | W103-98 | 43-25 | .632 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 69 | Thu Mar 14 | vs Thunder | W108-106 | 44-25 | .638 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 70 | Sat Mar 16 | at Nuggets | L100-102 | 44-26 | .629 | | Ball Arena · Denver, CO |
| 71 | Mon Mar 18 | at Blazers | L98-106 | 44-27 | .620 | ESPN | Moda Center · Portland, OR |
| 72 | Tue Mar 19 | at Clippers | L109-115 | 44-28 | .611 | NBA TV | Intuit Dome · Inglewood, CA |
| 73 | Thu Mar 21 | at Warriors | L89-112 | 44-29 | .603 | | Chase Center · San Francisco, CA |
| 74 | Sun Mar 24 | vs Nuggets | W124-88 | 45-29 | .608 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 75 | Wed Mar 27 | at Thunder | L99-107 | 45-30 | .600 | ESPN | Paycom Center · Oklahoma City, OK |
| 76 | Fri Mar 29 | at Celtics | L112-114 | 45-31 | .592 | NBA TV | TD Garden · Boston, MA |
| 77 | Sat Mar 30 | vs Magic | L116-121 | 45-32 | .584 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 78 | Mon Apr 1 | vs Pistons | W111-102 | 46-32 | .590 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 79 | Wed Apr 3 | at Pistons | W108-89 | 47-32 | .595 | | Little Caesars Arena · Detroit, MI |
| 80 | Fri Apr 5 | vs Celtics | L97-117 | 47-33 | .588 | ESPN | Gainbridge Fieldhouse · Indianapolis, IN |
| 81 | Sun Apr 7 | vs Nets | L96-108 | 47-34 | .580 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 82 | Wed Apr 10 | at Hawks | W135-134 | 48-34 | .585 | | State Farm Arena · Atlanta, GA |
| 1 | Sun Apr 14 | at Celtics | L74-84 | 0-1 | .000 | TNT | TD Garden · Boston, MA |
| 2 | Wed Apr 17 | at Celtics | L91-99 | 0-2 | .000 | TNT | TD Garden · Boston, MA |
| 3 | Fri Apr 19 | vs Celtics | L96-104 | 0-3 | .000 | ABC | Gainbridge Fieldhouse · Indianapolis, IN |
| 4 | Sun Apr 21 | vs Celtics | L106-110 | 0-4 | .000 | ABC | Gainbridge Fieldhouse · Indianapolis, IN |