| 1 | Tue Oct 16 | at Celtics | L87-105 | 0-1 | .000 | TNT | TD Garden · Boston, MA |
| 2 | Thu Oct 18 | vs Bulls | W127-108 | 1-1 | .500 | TNT | Wells Fargo Center · Philadelphia, PA |
| 3 | Sat Oct 20 | vs Magic | W116-115 | 2-1 | .667 | | Wells Fargo Center · Philadelphia, PA |
| 4 | Tue Oct 23 | at Pistons | L132-133 (OT) | 2-2 | .500 | NBA TV | Little Caesars Arena · Detroit, MI |
| 5 | Wed Oct 24 | at Bucks | L108-123 | 2-3 | .400 | ESPN | Fiserv Forum · Milwaukee, WI |
| 6 | Sat Oct 27 | vs Hornets | W105-103 | 3-3 | .500 | | Wells Fargo Center · Philadelphia, PA |
| 7 | Mon Oct 29 | vs Hawks | W113-92 | 4-3 | .571 | | Wells Fargo Center · Philadelphia, PA |
| 8 | Tue Oct 30 | at Raptors | L112-129 | 4-4 | .500 | NBA TV | Scotiabank Arena · Toronto, ON |
| 9 | Thu Nov 1 | vs Clippers | W122-113 | 5-4 | .556 | | Wells Fargo Center · Philadelphia, PA |
| 10 | Sat Nov 3 | vs Pistons | W109-99 | 6-4 | .600 | | Wells Fargo Center · Philadelphia, PA |
| 11 | Sun Nov 4 | at Nets | L97-122 | 6-5 | .545 | | Barclays Center · Brooklyn, NY |
| 12 | Wed Nov 7 | at Pacers | W100-94 | 7-5 | .583 | ESPN | Gainbridge Fieldhouse · Indianapolis, IN |
| 13 | Fri Nov 9 | vs Hornets | W133-132 (OT) | 8-5 | .615 | NBA TV | Wells Fargo Center · Philadelphia, PA |
| 14 | Sat Nov 10 | at Grizzlies | L106-112 (OT) | 8-6 | .571 | | FedExForum · Memphis, TN |
| 15 | Mon Nov 12 | at Heat | W124-114 | 9-6 | .600 | | Kaseya Center · Miami, FL |
| 16 | Wed Nov 14 | at Magic | L106-111 | 9-7 | .563 | | Amway Center · Orlando, FL |
| 17 | Fri Nov 16 | vs Jazz | W113-107 | 10-7 | .588 | | Wells Fargo Center · Philadelphia, PA |
| 18 | Sat Nov 17 | at Hornets | W122-119 (OT) | 11-7 | .611 | | Spectrum Center · Charlotte, NC |
| 19 | Mon Nov 19 | vs Suns | W119-114 | 12-7 | .632 | NBA TV | Wells Fargo Center · Philadelphia, PA |
| 20 | Wed Nov 21 | vs Pelicans | W121-120 | 13-7 | .650 | | Wells Fargo Center · Philadelphia, PA |
| 21 | Fri Nov 23 | vs Cavaliers | L112-121 | 13-8 | .619 | | Wells Fargo Center · Philadelphia, PA |
| 22 | Sun Nov 25 | at Nets | W127-125 | 14-8 | .636 | | Barclays Center · Brooklyn, NY |
| 23 | Wed Nov 28 | vs Knicks | W117-91 | 15-8 | .652 | NBA TV | Wells Fargo Center · Philadelphia, PA |
| 24 | Fri Nov 30 | vs Wizards | W123-98 | 16-8 | .667 | | Wells Fargo Center · Philadelphia, PA |
| 25 | Sun Dec 2 | vs Grizzlies | W103-95 | 17-8 | .680 | | Wells Fargo Center · Philadelphia, PA |
| 26 | Wed Dec 5 | at Raptors | L102-113 | 17-9 | .654 | ESPN | Scotiabank Arena · Toronto, ON |
| 27 | Fri Dec 7 | at Pistons | W117-111 | 18-9 | .667 | ESPN | Little Caesars Arena · Detroit, MI |
| 28 | Mon Dec 10 | vs Pistons | W116-102 | 19-9 | .679 | | Wells Fargo Center · Philadelphia, PA |
| 29 | Wed Dec 12 | vs Nets | L124-127 | 19-10 | .655 | | Wells Fargo Center · Philadelphia, PA |
| 30 | Fri Dec 14 | vs Pacers | L101-113 | 19-11 | .633 | ESPN | Wells Fargo Center · Philadelphia, PA |
| 31 | Sun Dec 16 | at Cavaliers | W128-105 | 20-11 | .645 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 32 | Mon Dec 17 | at Spurs | L96-123 | 20-12 | .625 | | AT&T Center · San Antonio, TX |
| 33 | Wed Dec 19 | vs Knicks | W131-109 | 21-12 | .636 | | Wells Fargo Center · Philadelphia, PA |
| 34 | Sat Dec 22 | vs Raptors | W126-101 | 22-12 | .647 | NBA TV | Wells Fargo Center · Philadelphia, PA |
| 35 | Tue Dec 25 | at Celtics | L114-121 (OT) | 22-13 | .629 | ABC | TD Garden · Boston, MA |
| 36 | Thu Dec 27 | at Jazz | W114-97 | 23-13 | .639 | TNT | Vivint Arena · Salt Lake City, UT |
| 37 | Sun Dec 30 | at Blazers | L95-129 | 23-14 | .622 | | Moda Center · Portland, OR |
| 38 | Tue Jan 1 | at Clippers | W119-113 | 24-14 | .632 | | Intuit Dome · Inglewood, CA |
| 39 | Wed Jan 2 | at Suns | W132-127 | 25-14 | .641 | | Footprint Center · Phoenix, AZ |
| 40 | Sat Jan 5 | vs Mavericks | W106-100 | 26-14 | .650 | | Wells Fargo Center · Philadelphia, PA |
| 41 | Tue Jan 8 | vs Wizards | W132-115 | 27-14 | .659 | | Wells Fargo Center · Philadelphia, PA |
| 42 | Wed Jan 9 | at Wizards | L106-123 | 27-15 | .643 | | Capital One Arena · Washington, D.C. |
| 43 | Fri Jan 11 | vs Hawks | L121-123 | 27-16 | .628 | | Wells Fargo Center · Philadelphia, PA |
| 44 | Sun Jan 13 | at Knicks | W108-105 | 28-16 | .636 | | Madison Square Garden · Manhattan, NY |
| 45 | Tue Jan 15 | vs T-wolves | W149-107 | 29-16 | .644 | NBA TV | Wells Fargo Center · Philadelphia, PA |
| 46 | Thu Jan 17 | at Pacers | W120-96 | 30-16 | .652 | TNT | Gainbridge Fieldhouse · Indianapolis, IN |
| 47 | Sat Jan 19 | vs Thunder | L115-117 | 30-17 | .638 | ABC | Wells Fargo Center · Philadelphia, PA |
| 48 | Mon Jan 21 | vs Rockets | W121-93 | 31-17 | .646 | TNT | Wells Fargo Center · Philadelphia, PA |
| 49 | Wed Jan 23 | vs Spurs | W122-120 | 32-17 | .653 | ESPN | Wells Fargo Center · Philadelphia, PA |
| 50 | Sat Jan 26 | at Nuggets | L110-126 | 32-18 | .640 | | Ball Arena · Denver, CO |
| 51 | Tue Jan 29 | at Lakers | W121-105 | 33-18 | .647 | TNT | Crypto.com Arena · Los Angeles, CA |
| 52 | Thu Jan 31 | at Warriors | W113-104 | 34-18 | .654 | TNT | Chase Center · San Francisco, CA |
| 53 | Sat Feb 2 | at Kings | L108-115 | 34-19 | .642 | | Golden 1 Center · Sacramento, CA |
| 54 | Tue Feb 5 | vs Raptors | L107-119 | 34-20 | .630 | TNT | Wells Fargo Center · Philadelphia, PA |
| 55 | Fri Feb 8 | vs Nuggets | W117-110 | 35-20 | .636 | ESPN | Wells Fargo Center · Philadelphia, PA |
| 56 | Sun Feb 10 | vs Lakers | W143-120 | 36-20 | .643 | ABC | Wells Fargo Center · Philadelphia, PA |
| 57 | Tue Feb 12 | vs Celtics | L109-112 | 36-21 | .632 | TNT | Wells Fargo Center · Philadelphia, PA |
| 58 | Wed Feb 13 | at Knicks | W126-111 | 37-21 | .638 | | Madison Square Garden · Manhattan, NY |
| 59 | Thu Feb 21 | vs Heat | W106-102 | 38-21 | .644 | | Wells Fargo Center · Philadelphia, PA |
| 60 | Sat Feb 23 | vs Blazers | L115-130 | 38-22 | .633 | | Wells Fargo Center · Philadelphia, PA |
| 61 | Mon Feb 25 | at Pelicans | W111-110 | 39-22 | .639 | NBA TV | Smoothie King Center · New Orleans, LA |
| 62 | Thu Feb 28 | at Thunder | W108-104 | 40-22 | .645 | TNT | Paycom Center · Oklahoma City, OK |
| 63 | Sat Mar 2 | vs Warriors | L117-120 | 40-23 | .635 | ABC | Wells Fargo Center · Philadelphia, PA |
| 64 | Tue Mar 5 | vs Magic | W114-106 | 41-23 | .641 | | Wells Fargo Center · Philadelphia, PA |
| 65 | Wed Mar 6 | at Bulls | L107-108 | 41-24 | .631 | ESPN | United Center · Chicago, IL |
| 66 | Fri Mar 8 | at Rockets | L91-107 | 41-25 | .621 | ESPN | Toyota Center · Houston, TX |
| 67 | Sun Mar 10 | vs Pacers | W106-89 | 42-25 | .627 | ABC | Wells Fargo Center · Philadelphia, PA |
| 68 | Tue Mar 12 | vs Cavaliers | W106-99 | 43-25 | .632 | | Wells Fargo Center · Philadelphia, PA |
| 69 | Fri Mar 15 | vs Kings | W123-114 | 44-25 | .638 | | Wells Fargo Center · Philadelphia, PA |
| 70 | Sun Mar 17 | at Bucks | W130-125 | 45-25 | .643 | ABC | Fiserv Forum · Milwaukee, WI |
| 71 | Tue Mar 19 | at Hornets | W118-114 | 46-25 | .648 | | Spectrum Center · Charlotte, NC |
| 72 | Wed Mar 20 | vs Celtics | W118-115 | 47-25 | .653 | ESPN | Wells Fargo Center · Philadelphia, PA |
| 73 | Sat Mar 23 | at Hawks | L127-129 | 47-26 | .644 | NBA TV | State Farm Arena · Atlanta, GA |
| 74 | Mon Mar 25 | at Magic | L98-119 | 47-27 | .635 | NBA TV | Amway Center · Orlando, FL |
| 75 | Thu Mar 28 | vs Nets | W123-110 | 48-27 | .640 | | Wells Fargo Center · Philadelphia, PA |
| 76 | Sat Mar 30 | at T-wolves | W118-109 | 49-27 | .645 | NBA TV | Target Center · Minneapolis, MN |
| 77 | Mon Apr 1 | at Mavericks | L102-122 | 49-28 | .636 | | American Airlines Center · Dallas, TX |
| 78 | Wed Apr 3 | at Hawks | L122-130 | 49-29 | .628 | | State Farm Arena · Atlanta, GA |
| 79 | Thu Apr 4 | vs Bucks | L122-128 | 49-30 | .620 | TNT | Wells Fargo Center · Philadelphia, PA |
| 80 | Sat Apr 6 | at Bulls | W116-96 | 50-30 | .625 | NBA TV | United Center · Chicago, IL |
| 81 | Tue Apr 9 | at Heat | L99-122 | 50-31 | .617 | | Kaseya Center · Miami, FL |
| 82 | Wed Apr 10 | vs Bulls | W125-109 | 51-31 | .622 | | Wells Fargo Center · Philadelphia, PA |
| 1 | Sat Apr 13 | vs Nets | L102-111 | 0-1 | .000 | ESPN | Wells Fargo Center · Philadelphia, PA |
| 2 | Mon Apr 15 | vs Nets | W145-123 | 1-1 | .500 | TNT | Wells Fargo Center · Philadelphia, PA |
| 3 | Thu Apr 18 | at Nets | W131-115 | 2-1 | .667 | TNT | Barclays Center · Brooklyn, NY |
| 4 | Sat Apr 20 | at Nets | W112-108 | 3-1 | .750 | TNT | Barclays Center · Brooklyn, NY |
| 5 | Tue Apr 23 | vs Nets | W122-100 | 4-1 | .800 | TNT | Wells Fargo Center · Philadelphia, PA |
| 1 | Sat Apr 27 | at Raptors | L95-108 | 0-1 | .000 | TNT | Scotiabank Arena · Toronto, ON |
| 2 | Mon Apr 29 | at Raptors | W94-89 | 1-1 | .500 | TNT | Scotiabank Arena · Toronto, ON |
| 3 | Thu May 2 | vs Raptors | W116-95 | 2-1 | .667 | ESPN | Wells Fargo Center · Philadelphia, PA |
| 4 | Sun May 5 | vs Raptors | L96-101 | 2-2 | .500 | ABC | Wells Fargo Center · Philadelphia, PA |
| 5 | Tue May 7 | at Raptors | L89-125 | 2-3 | .400 | TNT | Scotiabank Arena · Toronto, ON |
| 6 | Thu May 9 | vs Raptors | W112-101 | 3-3 | .500 | ESPN | Wells Fargo Center · Philadelphia, PA |
| 7 | Sun May 12 | at Raptors | L90-92 | 3-4 | .429 | TNT | Scotiabank Arena · Toronto, ON |