| 1 | Wed Oct 23 | vs Celtics | W107-93 | 1-0 | 1.000 | Wells Fargo Center · Philadelphia, PA |
| 2 | Sat Oct 26 | at Pistons | W117-111 | 2-0 | 1.000 | Little Caesars Arena · Detroit, MI |
| 3 | Mon Oct 28 | at Hawks | W105-103 | 3-0 | 1.000 | State Farm Arena · Atlanta, GA |
| 4 | Wed Oct 30 | vs T-wolves | W117-95 | 4-0 | 1.000 | Wells Fargo Center · Philadelphia, PA |
| 5 | Sat Nov 2 | at Blazers | W129-128 | 5-0 | 1.000 | Moda Center · Portland, OR |
| 6 | Mon Nov 4 | at Suns | L109-114 | 5-1 | .833 | Footprint Center · Phoenix, AZ |
| 7 | Wed Nov 6 | at Jazz | L104-106 | 5-2 | .714 | Vivint Arena · Salt Lake City, UT |
| 8 | Fri Nov 8 | at Nuggets | L97-100 | 5-3 | .625 | Ball Arena · Denver, CO |
| 9 | Sun Nov 10 | vs Hornets | W114-106 | 6-3 | .667 | Wells Fargo Center · Philadelphia, PA |
| 10 | Tue Nov 12 | vs Cavaliers | W98-97 | 7-3 | .700 | Wells Fargo Center · Philadelphia, PA |
| 11 | Wed Nov 13 | at Magic | L97-112 | 7-4 | .636 | Amway Center · Orlando, FL |
| 12 | Fri Nov 15 | at Thunder | L119-127 (OT) | 7-5 | .583 | Paycom Center · Oklahoma City, OK |
| 13 | Sun Nov 17 | atCavaliers | W114-95 | 8-5 | .615 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 14 | Wed Nov 20 | vs Knicks | W109-104 | 9-5 | .643 | Wells Fargo Center · Philadelphia, PA |
| 15 | Fri Nov 22 | vs Spurs | W115-104 | 10-5 | .667 | Wells Fargo Center · Philadelphia, PA |
| 16 | Sat Nov 23 | vs Heat | W113-86 | 11-5 | .688 | Wells Fargo Center · Philadelphia, PA |
| 17 | Mon Nov 25 | at Raptors | L96-101 | 11-6 | .647 | Scotiabank Arena · Toronto, ON |
| 18 | Wed Nov 27 | vs Kings | W97-91 | 12-6 | .667 | Wells Fargo Center · Philadelphia, PA |
| 19 | Fri Nov 29 | atKnicks | W101-95 | 13-6 | .684 | Madison Square Garden · Manhattan, NY |
| 20 | Sat Nov 30 | vs Pacers | W119-116 | 14-6 | .700 | Wells Fargo Center · Philadelphia, PA |
| 21 | Mon Dec 2 | vsJazz | W103-94 | 15-6 | .714 | Wells Fargo Center · Philadelphia, PA |
| 22 | Thu Dec 5 | at Wizards | L113-119 | 15-7 | .682 | Capital One Arena · Washington, D.C. |
| 23 | Sat Dec 7 | vsCavaliers | W141-94 | 16-7 | .696 | Wells Fargo Center · Philadelphia, PA |
| 24 | Sun Dec 8 | vsRaptors | W110-104 | 17-7 | .708 | Wells Fargo Center · Philadelphia, PA |
| 25 | Tue Dec 10 | vsNuggets | W97-92 | 18-7 | .720 | Wells Fargo Center · Philadelphia, PA |
| 26 | Thu Dec 12 | atCeltics | W115-109 | 19-7 | .731 | TD Garden · Boston, MA |
| 27 | Fri Dec 13 | vs Pelicans | W116-109 | 20-7 | .741 | Wells Fargo Center · Philadelphia, PA |
| 28 | Sun Dec 15 | at Nets | L89-109 | 20-8 | .714 | Barclays Center · Brooklyn, NY |
| 29 | Wed Dec 18 | vsHeat | L104-108 | 20-9 | .690 | Wells Fargo Center · Philadelphia, PA |
| 30 | Fri Dec 20 | vs Mavericks | L98-117 | 20-10 | .667 | Wells Fargo Center · Philadelphia, PA |
| 31 | Sat Dec 21 | vsWizards | W125-108 | 21-10 | .677 | Wells Fargo Center · Philadelphia, PA |
| 32 | Mon Dec 23 | atPistons | W125-109 | 22-10 | .688 | Little Caesars Arena · Detroit, MI |
| 33 | Wed Dec 25 | vs Bucks | W121-109 | 23-10 | .697 | Wells Fargo Center · Philadelphia, PA |
| 34 | Fri Dec 27 | atMagic | L97-98 | 23-11 | .676 | Amway Center · Orlando, FL |
| 35 | Sat Dec 28 | atHeat | L116-117 (OT) | 23-12 | .657 | FTX Arena · Miami, FL |
| 36 | Tue Dec 31 | atPacers | L97-115 | 23-13 | .639 | Gainbridge Fieldhouse · Indianapolis, IN |
| 37 | Fri Jan 3 | at Rockets | L108-118 | 23-14 | .622 | Toyota Center · Houston, TX |
| 38 | Mon Jan 6 | vsThunder | W120-113 | 24-14 | .632 | Wells Fargo Center · Philadelphia, PA |
| 39 | Thu Jan 9 | vsCeltics | W109-98 | 25-14 | .641 | Wells Fargo Center · Philadelphia, PA |
| 40 | Sat Jan 11 | atMavericks | L91-109 | 25-15 | .625 | American Airlines Center · Dallas, TX |
| 41 | Mon Jan 13 | atPacers | L95-101 | 25-16 | .610 | Gainbridge Fieldhouse · Indianapolis, IN |
| 42 | Wed Jan 15 | vsNets | W117-106 | 26-16 | .619 | Wells Fargo Center · Philadelphia, PA |
| 43 | Fri Jan 17 | vs Bulls | W100-89 | 27-16 | .628 | Wells Fargo Center · Philadelphia, PA |
| 44 | Sat Jan 18 | atKnicks | W90-87 | 28-16 | .636 | Madison Square Garden · Manhattan, NY |
| 45 | Mon Jan 20 | atNets | W117-111 | 29-16 | .644 | Barclays Center · Brooklyn, NY |
| 46 | Wed Jan 22 | atRaptors | L95-107 | 29-17 | .630 | Scotiabank Arena · Toronto, ON |
| 47 | Sat Jan 25 | vs Lakers | W108-91 | 30-17 | .638 | Wells Fargo Center · Philadelphia, PA |
| 48 | Tue Jan 28 | vs Warriors | W115-104 | 31-17 | .646 | Wells Fargo Center · Philadelphia, PA |
| 49 | Thu Jan 30 | atHawks | L117-127 | 31-18 | .633 | State Farm Arena · Atlanta, GA |
| 50 | Sat Feb 1 | atCeltics | L95-116 | 31-19 | .620 | TD Garden · Boston, MA |
| 51 | Mon Feb 3 | atHeat | L106-137 | 31-20 | .608 | FTX Arena · Miami, FL |
| 52 | Thu Feb 6 | atBucks | L101-112 | 31-21 | .596 | Fiserv Forum · Milwaukee, WI |
| 53 | Fri Feb 7 | vs Grizzlies | W119-107 | 32-21 | .604 | Wells Fargo Center · Philadelphia, PA |
| 54 | Sun Feb 9 | vsBulls | W118-111 | 33-21 | .611 | Wells Fargo Center · Philadelphia, PA |
| 55 | Tue Feb 11 | vs Clippers | W110-103 | 34-21 | .618 | Wells Fargo Center · Philadelphia, PA |
| 56 | Thu Feb 20 | vsNets | W112-104 (OT) | 35-21 | .625 | Wells Fargo Center · Philadelphia, PA |
| 57 | Sat Feb 22 | atBucks | L98-119 | 35-22 | .614 | Fiserv Forum · Milwaukee, WI |
| 58 | Mon Feb 24 | vsHawks | W129-112 | 36-22 | .621 | Wells Fargo Center · Philadelphia, PA |
| 59 | Wed Feb 26 | atCavaliers | L94-108 | 36-23 | .610 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 60 | Thu Feb 27 | vsKnicks | W115-106 | 37-23 | .617 | Wells Fargo Center · Philadelphia, PA |
| 61 | Sun Mar 1 | atClippers | L130-136 | 37-24 | .607 | Crypto.com Arena · Los Angeles, CA |
| 62 | Tue Mar 3 | atLakers | L107-120 | 37-25 | .597 | Crypto.com Arena · Los Angeles, CA |
| 63 | Thu Mar 5 | atKings | W125-108 | 38-25 | .603 | Golden 1 Center · Sacramento, CA |
| 64 | Sat Mar 7 | atWarriors | L114-118 | 38-26 | .594 | Chase Center · San Francisco, CA |
| 65 | Wed Mar 11 | vsPistons | W124-106 | 39-26 | .600 | Wells Fargo Center · Philadelphia, PA |
| 66 | Sat Aug 1 | atPacers | L121-127 | 39-27 | .591 | Gainbridge Fieldhouse · Indianapolis, IN |
| 67 | Mon Aug 3 | vsSpurs | W132-130 | 40-27 | .597 | Wells Fargo Center · Philadelphia, PA |
| 68 | Wed Aug 5 | atWizards | W107-98 | 41-27 | .603 | Capital One Arena · Washington, D.C. |
| 69 | Fri Aug 7 | vsMagic | W108-101 | 42-27 | .609 | Wells Fargo Center · Philadelphia, PA |
| 70 | Sun Aug 9 | atBlazers | L121-124 | 42-28 | .600 | Moda Center · Portland, OR |
| 71 | Tue Aug 11 | vsSuns | L117-130 | 42-29 | .592 | Wells Fargo Center · Philadelphia, PA |
| 72 | Wed Aug 12 | vsRaptors | L121-125 | 42-30 | .583 | Wells Fargo Center · Philadelphia, PA |
| 73 | Fri Aug 14 | atRockets | W134-96 | 43-30 | .589 | Toyota Center · Houston, TX |
| 1 | Mon Aug 17 | atCeltics | L101-109 | 0-1 | .000 | TD Garden · Boston, MA |
| 2 | Wed Aug 19 | atCeltics | L101-128 | 0-2 | .000 | TD Garden · Boston, MA |
| 3 | Fri Aug 21 | vsCeltics | L94-102 | 0-3 | .000 | Wells Fargo Center · Philadelphia, PA |
| 4 | Sun Aug 23 | vsCeltics | L106-110 | 0-4 | .000 | Wells Fargo Center · Philadelphia, PA |
