| 1 | Tue Oct 20 | vs Thunder | 9:30 PM | 0-0 | .000 | NBC | Frost Bank Center · San Antonio, TX |
| 2 | Fri Oct 23 | vsRockets | 9:30 PM | 0-0 | .000 | Prime Video | Frost Bank Center · San Antonio, TX |
| 3 | Sat Oct 24 | atMavericks | 8:00 PM | 0-0 | .000 | | American Airlines Center · Dallas, TX |
| 4 | Tue Oct 27 | vsKings | 8:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 5 | Wed Oct 28 | atJazz | 9:00 PM | 0-0 | .000 | | Vivint Arena · Salt Lake City, UT |
| 6 | Sat Oct 31 | vsT-wolves | 8:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 7 | Mon Nov 2 | vsJazz | 8:30 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 8 | Wed Nov 4 | vsMavericks | 9:30 PM | 0-0 | .000 | ESPN | Frost Bank Center · San Antonio, TX |
| 9 | Fri Nov 6 | atKings | 10:00 PM | 0-0 | .000 | | Golden 1 Center · Sacramento, CA |
| 10 | Sat Nov 7 | atBlazers | 10:00 PM | 0-0 | .000 | | Moda Center · Portland, OR |
| 11 | Mon Nov 9 | atSuns | 9:00 PM | 0-0 | .000 | | Mortgage Matchup Center · Phoenix, AZ |
| 12 | Wed Nov 11 | atBulls | 8:00 PM | 0-0 | .000 | | United Center · Chicago, IL |
| 13 | Fri Nov 13 | vsWarriors | 9:30 PM | 0-0 | .000 | Prime Video | Frost Bank Center · San Antonio, TX |
| 14 | Sun Nov 15 | atJazz | 5:00 PM | 0-0 | .000 | | Vivint Arena · Salt Lake City, UT |
| 15 | Tue Nov 17 | vsPistons | 8:00 PM | 0-0 | .000 | NBC | Frost Bank Center · San Antonio, TX |
| 16 | Thu Nov 19 | vsClippers | 8:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 17 | Sat Nov 21 | vsPelicans | 8:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 18 | Mon Nov 23 | atKings | 10:00 PM | 0-0 | .000 | | Golden 1 Center · Sacramento, CA |
| 19 | Wed Nov 25 | atBlazers | 10:00 PM | 0-0 | .000 | ESPN | Moda Center · Portland, OR |
| 20 | Fri Nov 27 | vsLakers | 9:30 PM | 0-0 | .000 | Prime Video | Frost Bank Center · San Antonio, TX |
| 21 | Sun Nov 29 | vsCeltics | 4:00 PM | 0-0 | .000 | NBA TV | Frost Bank Center · San Antonio, TX |
| 22 | Mon Nov 30 | atBucks | 8:00 PM | 0-0 | .000 | | Fiserv Forum · Milwaukee, WI |
| 23 | Thu Dec 3 | vsRaptors | 8:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 24 | Sun Dec 13 | vsClippers | 7:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 25 | Tue Dec 15 | atCavaliers | 8:00 PM | 0-0 | .000 | NBC | Rocket Mortgage FieldHouse · Cleveland, OH |
| 26 | Wed Dec 16 | atRaptors | 7:30 PM | 0-0 | .000 | | Scotiabank Arena · Toronto, ON |
| 27 | Fri Dec 18 | vsBulls | 8:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 28 | Sun Dec 20 | atPelicans | 7:00 PM | 0-0 | .000 | | Smoothie King Center · New Orleans, LA |
| 29 | Mon Dec 21 | vsBucks | 8:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 30 | Wed Dec 23 | atNets | 7:30 PM | 0-0 | .000 | | Barclays Center · Brooklyn, NY |
| 31 | Fri Dec 25 | atKnicks | 12:00 PM | 0-0 | .000 | ABC | Madison Square Garden · Manhattan, NY |
| 32 | Sun Dec 27 | vsHawks | 7:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 33 | Tue Dec 29 | atGrizzlies | 8:00 PM | 0-0 | .000 | | FedExForum · Memphis, TN |
| 34 | Thu Dec 31 | atHornets | 1:00 PM | 0-0 | .000 | NBA TV | Spectrum Center · Charlotte, NC |
| 35 | Fri Jan 1 | atWizards | 5:00 PM | 0-0 | .000 | NBA TV | Capital One Arena · Washington, D.C. |
| 36 | Sun Jan 3 | atT-wolves | 7:00 PM | 0-0 | .000 | NBA TV | Target Center · Minneapolis, MN |
| 37 | Wed Jan 6 | vsPacers | 8:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 38 | Fri Jan 8 | vsGrizzlies | 8:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 39 | Sun Jan 10 | atHawks | 3:00 PM | 0-0 | .000 | | State Farm Arena · Atlanta, GA |
| 40 | Thu Jan 14 | vsPelicans | 2:00 PM | 0-0 | .000 | Prime Video | Frost Bank Center · San Antonio, TX |
| 41 | Sun Jan 17 | atPelicans | 10:30 AM | 0-0 | .000 | Prime Video | Smoothie King Center · New Orleans, LA |
| 42 | Wed Jan 20 | vsHeat | 9:30 PM | 0-0 | .000 | ESPN | Frost Bank Center · San Antonio, TX |
| 43 | Fri Jan 22 | vsT-wolves | 9:30 PM | 0-0 | .000 | ESPN | Frost Bank Center · San Antonio, TX |
| 44 | Sun Jan 24 | vsBlazers | 3:30 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 45 | Tue Jan 26 | vsRockets | 8:00 PM | 0-0 | .000 | NBC | Frost Bank Center · San Antonio, TX |
| 46 | Wed Jan 27 | vsHornets | 8:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 47 | Sat Jan 30 | atWarriors | 5:30 PM | 0-0 | .000 | ABC | Chase Center · San Francisco, CA |
| 48 | Mon Feb 1 | atWarriors | 10:00 PM | 0-0 | .000 | NBCSN | Chase Center · San Francisco, CA |
| 49 | Tue Feb 2 | atClippers | 10:30 PM | 0-0 | .000 | | Intuit Dome · Inglewood, CA |
| 50 | Thu Feb 4 | vsMagic | 8:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 51 | Sat Feb 6 | vsLakers | 8:30 PM | 0-0 | .000 | ABC | Frost Bank Center · San Antonio, TX |
| 52 | Tue Feb 9 | atMavericks | 8:00 PM | 0-0 | .000 | NBC | American Airlines Center · Dallas, TX |
| 53 | Thu Feb 11 | atThunder | 9:30 PM | 0-0 | .000 | Prime Video | Paycom Center · Oklahoma City, OK |
| 54 | Sat Feb 13 | atMagic | 7:00 PM | 0-0 | .000 | | Kia Center · Orlando, FL |
| 55 | Mon Feb 15 | atHeat | 5:00 PM | 0-0 | .000 | NBC | Kaseya Center · Miami, FL |
| 56 | Wed Feb 17 | atGrizzlies | 8:00 PM | 0-0 | .000 | | FedExForum · Memphis, TN |
| 57 | Thu Feb 18 | atT-wolves | 7:30 PM | 0-0 | .000 | Prime Video | Target Center · Minneapolis, MN |
| 58 | Fri Feb 26 | vsGrizzlies | 8:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 59 | Sun Feb 28 | vsNuggets | 1:00 PM | 0-0 | .000 | ABC | Frost Bank Center · San Antonio, TX |
| 60 | Wed Mar 3 | atNuggets | 10:00 PM | 0-0 | .000 | ESPN | Ball Arena · Denver, CO |
| 61 | Fri Mar 5 | atRockets | 9:30 PM | 0-0 | .000 | ESPN | Toyota Center · Houston, TX |
| 62 | Sun Mar 7 | vsKnicks | 7:30 PM | 0-0 | .000 | NBC | Frost Bank Center · San Antonio, TX |
| 63 | Tue Mar 9 | vsWizards | 8:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 64 | Thu Mar 11 | vs76ers | 7:30 PM | 0-0 | .000 | Prime Video | Frost Bank Center · San Antonio, TX |
| 65 | Sun Mar 14 | atThunder | 2:30 PM | 0-0 | .000 | ABC | Paycom Center · Oklahoma City, OK |
| 66 | Tue Mar 16 | atRockets | 8:30 PM | 0-0 | .000 | | Toyota Center · Houston, TX |
| 67 | Thu Mar 18 | vsNets | 8:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 68 | Fri Mar 19 | vsMavericks | 8:00 PM | 0-0 | .000 | NBA TV | Frost Bank Center · San Antonio, TX |
| 69 | Sun Mar 21 | at76ers | 7:30 PM | 0-0 | .000 | NBC | Xfinity Mobile Arena · Philadelphia, PA |
| 70 | Wed Mar 24 | atCeltics | 7:30 PM | 0-0 | .000 | ESPN | TD Garden · Boston, MA |
| 71 | Thu Mar 25 | atPacers | 7:00 PM | 0-0 | .000 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 72 | Sat Mar 27 | atPistons | 3:00 PM | 0-0 | .000 | Prime Video | Little Caesars Arena · Detroit, MI |
| 73 | Mon Mar 29 | vsSuns | 9:30 PM | 0-0 | .000 | NBCSN | Frost Bank Center · San Antonio, TX |
| 74 | Wed Mar 31 | vsSuns | 8:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 75 | Fri Apr 2 | atClippers | 10:30 PM | 0-0 | .000 | | Intuit Dome · Inglewood, CA |
| 76 | Sun Apr 4 | atLakers | 10:00 PM | 0-0 | .000 | NBC | Crypto.com Arena · Los Angeles, CA |
| 77 | Tue Apr 6 | vsKings | 8:00 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
| 78 | Wed Apr 7 | vsCavaliers | 7:30 PM | 0-0 | .000 | ESPN | Frost Bank Center · San Antonio, TX |
| 79 | Fri Apr 9 | vsNuggets | 9:30 PM | 0-0 | .000 | Prime Video | Frost Bank Center · San Antonio, TX |
| 80 | Sun Apr 11 | vsBlazers | 8:30 PM | 0-0 | .000 | | Frost Bank Center · San Antonio, TX |
